TRPC1: The housekeeper of the hippocampus

被引：1
|
作者：
Skerjanz, Julia [1 ]
Bauernhofer, Lena [2 ,8 ]
Lenk, Kerstin [3 ,8 ]
Emmerstorfer-Augustin, Anita [4 ,8 ]
Leitinger, Gerd [5 ,8 ,9 ]
Reichmann, Florian [6 ,8 ]
Stockner, Thomas [7 ]
Groschner, Klaus [1 ]
Tiapko, Oleksandra [1 ,8 ,9 ]
机构：
[1] Med Univ Graz, Gottfried Schatz Res Ctr, Div Med Phys & Biophys, Graz, Austria
[2] Karl Franzens Univ Graz, Inst Mol Biosci, Biophys Div, NAWI Graz, Graz, Austria
[3] Graz Univ Technol, Inst Neural Engn, Graz, Austria
[4] Graz Univ Technol, Inst Mol Biotechnol, Graz, Austria
[5] Med Univ Graz, Gottfried Schatz Res Ctr, Div Cell Biol Histol & Embryol, Graz, Austria
[6] Med Univ Graz, Otto Loewi Res Ctr, Div Pharmacol, Graz, Austria
[7] Med Univ Vienna, Dept Pharmacol, Vienna, Austria
[8] BioTechMed Graz, Graz, Austria
[9] MEFOgraz, Graz, Austria
来源：
CELL CALCIUM | 2024年 / 123卷
基金：
奥地利科学基金会;
关键词：
TRPC1; Hippocampus; ER homeostasis; TRPC ligands; POTENTIAL CHANNEL 1; CATION CHANNEL; ENDOPLASMIC-RETICULUM; SUBUNIT COMPOSITION; ION CHANNELS; CA2+ ENTRY; RECEPTOR; CALCIUM; ACTIVATION; RILUZOLE;
D O I：
10.1016/j.ceca.2024.102933
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.
引用
收藏
页数：9
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