Tinospora capillipes;
Clerodane diterpenoid;
Antibacterial;
Anti-inflammatory;
TNF-alpha and NO production;
FURANODITERPENOIDS;
SAGITTATA;
ALKALOIDS;
LEAVES;
D O I:
10.1002/cbdv.202401033
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Four new clerodane diterpenoids, namely tinocapills A-D (1-4), and one known analogue (5) were isolated from the roots of Tinospora capillipes in the present study. The structures of these new compounds, including their absolute configurations, were determined through a combination of detailed spectroscopic analysis and theoretical statistical approaches, including electronic circular dichroism (ECD) analyses and quantum mechanical (QM)-NMR methods. Additionally, the stereostructure of 5 was confirmed via X-ray diffraction analysis. Furthermore, all these isolates were evaluated for their antibacterial and anti-inflammatory activities. Compounds 1, 2 and 5 demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with MICs ranging from 4-64 mu g/mL, and compounds 3 and 4 exhibited potential anti-inflammatory effects by suppressing LPS-induced TNF-alpha and NO releases in RAW264.7 cells.
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Beutler, JA
McCall, KL
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
McCall, KL
Herbert, K
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Herbert, K
Herald, DL
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Herald, DL
Pettit, GR
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Pettit, GR
Johnson, T
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Johnson, T
Shoemaker, RH
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Shoemaker, RH
Boyd, MR
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Department of Chemical Engineering, Yibin University, Yibin
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Gao Y.
Niu Y.-F.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Graduate University of Chinese Academy of Sciences, Beijing
Yunnan University, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Niu Y.-F.
Wang F.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Wang F.
Hai P.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemical Engineering, Yibin University, Yibin
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Hai P.
Wang F.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Wang F.
Fang Y.-D.
论文数: 0引用数: 0
h-index: 0
机构:
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Fang Y.-D.
Xiong W.-Y.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, YunnanState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Xiong W.-Y.
Liu J.-K.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
School of Pharmaceutical Sciences, South-Central University for Nationalities, WuhanState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
机构:
Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Haque, Md Areeful
Jantan, Ibrahim
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Jantan, Ibrahim
Bukhari, Syed Nasir Abbas
论文数: 0引用数: 0
h-index: 0
机构:
Al Jouf Univ, Coll Pharm, Pharmaceut Chem Dept, Sakaka Al Jouf 2014, Saudi ArabiaUniv Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
机构:
Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Korea Res Inst Biosci & Biotechnol, Taejon 305333, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Hung, Tran Manh
Dang, Nguyen Hai
论文数: 0引用数: 0
h-index: 0
机构:
Vietnamese Acad Sci & Technol, Inst Nat Prod Chem, Hanoi, VietnamCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Dang, Nguyen Hai
Kim, Jin Cheol
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Chem Technol, Taejon 305600, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Kim, Jin Cheol
论文数: 引用数:
h-index:
机构:
Choi, Jae Sue
Lee, Hyeong Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Taejon 305333, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Lee, Hyeong Kyu
Min, Byung-Sun
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Beutler, JA
McCall, KL
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
McCall, KL
Herbert, K
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Herbert, K
Herald, DL
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Herald, DL
Pettit, GR
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Pettit, GR
Johnson, T
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Johnson, T
Shoemaker, RH
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
Shoemaker, RH
Boyd, MR
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Department of Chemical Engineering, Yibin University, Yibin
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Gao Y.
Niu Y.-F.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Graduate University of Chinese Academy of Sciences, Beijing
Yunnan University, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Niu Y.-F.
Wang F.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Wang F.
Hai P.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemical Engineering, Yibin University, Yibin
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Hai P.
Wang F.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Wang F.
Fang Y.-D.
论文数: 0引用数: 0
h-index: 0
机构:
BioBioPha Co., Ltd, KunmingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Fang Y.-D.
Xiong W.-Y.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, YunnanState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
Xiong W.-Y.
Liu J.-K.
论文数: 0引用数: 0
h-index: 0
机构:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
School of Pharmaceutical Sciences, South-Central University for Nationalities, WuhanState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan
机构:
Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Haque, Md Areeful
Jantan, Ibrahim
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
Jantan, Ibrahim
Bukhari, Syed Nasir Abbas
论文数: 0引用数: 0
h-index: 0
机构:
Al Jouf Univ, Coll Pharm, Pharmaceut Chem Dept, Sakaka Al Jouf 2014, Saudi ArabiaUniv Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
机构:
Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Korea Res Inst Biosci & Biotechnol, Taejon 305333, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Hung, Tran Manh
Dang, Nguyen Hai
论文数: 0引用数: 0
h-index: 0
机构:
Vietnamese Acad Sci & Technol, Inst Nat Prod Chem, Hanoi, VietnamCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Dang, Nguyen Hai
Kim, Jin Cheol
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Chem Technol, Taejon 305600, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Kim, Jin Cheol
论文数: 引用数:
h-index:
机构:
Choi, Jae Sue
Lee, Hyeong Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Taejon 305333, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
Lee, Hyeong Kyu
Min, Byung-Sun
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South KoreaCatholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea