New Clerodane Diterpenoids from Tinospora Capillipes with Antibacterial and Anti-Inflammatory Properties

被引:3
作者
Song, Yuan-Ze [1 ]
Yuan, Chao [2 ]
Li, Wen-Juan [3 ]
Song, Qing-Jiang [1 ]
Zhu, Wen-Hao [1 ]
Zhang, Juan [4 ]
机构
[1] Zibo Linzi Tradit Chinese Med Hosp, Zibo 255000, Peoples R China
[2] Zoucheng Adm Market Regulat, Zoucheng 273100, Peoples R China
[3] Dis Prevent & Control Ctr Yanzhou Dist, Clin Lab, Jining 272100, Peoples R China
[4] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China
基金
中国国家自然科学基金;
关键词
Tinospora capillipes; Clerodane diterpenoid; Antibacterial; Anti-inflammatory; TNF-alpha and NO production; FURANODITERPENOIDS; SAGITTATA; ALKALOIDS; LEAVES;
D O I
10.1002/cbdv.202401033
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Four new clerodane diterpenoids, namely tinocapills A-D (1-4), and one known analogue (5) were isolated from the roots of Tinospora capillipes in the present study. The structures of these new compounds, including their absolute configurations, were determined through a combination of detailed spectroscopic analysis and theoretical statistical approaches, including electronic circular dichroism (ECD) analyses and quantum mechanical (QM)-NMR methods. Additionally, the stereostructure of 5 was confirmed via X-ray diffraction analysis. Furthermore, all these isolates were evaluated for their antibacterial and anti-inflammatory activities. Compounds 1, 2 and 5 demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with MICs ranging from 4-64 mu g/mL, and compounds 3 and 4 exhibited potential anti-inflammatory effects by suppressing LPS-induced TNF-alpha and NO releases in RAW264.7 cells.
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页数:7
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