Nutrient sensing of mTORC1 signaling in cancer and aging

被引：2

作者：

Jiang, Cong ^{[1
]}

Tan, Xiao ^{[1
]}

Liu, Ning ^{[3
]}

Yan, Peiqiang ^{[2
]}

Hou, Tao ^{[2
]}

Wei, Wenyi ^{[2
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Canc Ctr, Sch Med, Shanghai 200092, Peoples R China

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[3] Shanghai Ocean Univ, Coll Food Sci & Technol, Int Res Ctr Food & Hlth, Shanghai 201306, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2024年 / 106-107卷

关键词：

MTOR; Nutrient sensing; Amino acid; Kinase; Tumorigenesis; MTORC1; MTORC2; Phosphorylation; TUBEROUS SCLEROSIS COMPLEX; TUMOR-SUPPRESSOR COMPLEX; TRANSFER-RNA SYNTHETASE; AMINO-ACID SUFFICIENCY; EXTENDS LIFE-SPAN; CRYO-EM STRUCTURE; P70; S6; KINASE; RAG GTPASES; BETA-TRCP; CELL-GROWTH;

D O I：

10.1016/j.semcancer.2024.08.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanistic target of rapamycin complex 1 (mTORC1) is indispensable for preserving cellular and organismal homeostasis by balancing the anabolic and catabolic processes in response to various environmental cues, such as nutrients, growth factors, energy status, oxygen levels, and stress. Dysregulation of mTORC1 signaling is associated with the progression of many types of human disorders including cancer, age-related diseases, neurodegenerative disorders, and metabolic diseases. The way mTORC1 senses various upstream signals and converts them into specific downstream responses remains a crucial question with significant impacts for our perception of the related physiological and pathological process. In this review, we discuss the recent molecular and functional insights into the nutrient sensing of the mTORC1 signaling pathway, along with the emerging role of deregulating nutrient-mTORC1 signaling in cancer and age-related disorders.

引用

页码：1 / 12

页数：12

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