Conjugated Linoleic Acid in Cancer Therapy

被引：1

作者：

George, Jeneesha ^{[1
]}

Ghosh, Asit Ranjan ^{[1
]}

机构：

[1] Vellore Inst Technol VIT, Sch Biosci & Technol SBST, Dept Integrat Biol, Vellore 632014, Tamil Nadu, India

来源：

CURRENT DRUG DELIVERY | 2025年 / 22卷 / 04期

关键词：

Probiotics; CLA; biohydrogenation; functional food; cancer; prevention; POSTMENOPAUSAL BREAST-CANCER; FATTY-ACIDS; CLA SUPPLEMENTATION; ANTICANCER ACTIVITY; COLORECTAL-CANCER; ADIPOSE-TISSUE; DIETARY; CELLS; RISK; ISOMERS;

D O I：

10.2174/0115672018325362240811164655

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Conjugated Linoleic Acid (CLA) is a polyunsaturated dietary fatty acid. Probiotics can biohydrogenate CLA with multiple health benefits, especially in cancer treatment. In vitro, in vivo, and clinical studies have confirmed CLA isomers to possess anti-cancer activity. CLA has demonstrated its potential as an alternative treatment for cancer and also used as an adjuvant to reduce the side effects of existing treatment methods. The mechanism of the anticancer activity of CLA is still not clear; however, it may involve intervention with the cell cycle and modulation of gene expression. A greater potential of CLA for cancer treatment has been supported by more and more clinical trials to evaluate its potential. Some advanced technologies are in progress to overcome the flaws of current methods and enhance the microbial production of CLA. In conclusion, nutritional enrichment as a functional food and direct consumption of CLA may contribute to cancer management.

引用

页码：450 / 464

页数：15

共 102 条

[1] Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice [J].

Abd El-Gawad, Abdelrahman M. ;

El-Hassan, Diea G. Abo ;

Aboul-Enein, Ahmed M. ;

Abdelgayed, Sherein S. ;

Aly, Salwa A. ;

Esmat, Gamal ;

Mostafa, Amr A. ;

Bakr, Mohamed H. ;

Ali, Rida A. ;

Ayoub, Mahmoud A. .

VETERINARY WORLD, 2021, 14 (03) :696-708

[2]

[Anonymous], 2001, Evaluation of health and nutritional properties of powder milk with live lactic acid bacteria

[3] Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women [J].

Aro, A ;

Männistö, S ;

Salminen, I ;

Ovaskainen, ML ;

Kataja, V ;

Uusitupa, M .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2000, 38 (02) :151-157

[4] CLA Has a Useful Effect on Bone Markers in Patients with Rheumatoid Arthritis [J].

Aryaeian, N. ;

Shahram, F. ;

Djalali, M. .

LIPIDS, 2016, 51 (12) :1397-1405

[5] Immunoregulatory Mechanisms Underlying Prevention of Colitis-Associated Colorectal Cancer by Probiotic Bacteria [J].

Bassaganya-Riera, Josep ;

Viladomiu, Monica ;

Pedragosa, Mireia ;

De Simone, Claudio ;

Hontecillas, Raquel .

PLOS ONE, 2012, 7 (04)

[6] Probiotics for cancer alternative prevention and treatment [J].

Bedada, Tesfaye Legesse ;

Feto, Tatek Kasim ;

Awoke, Kaleab Sebsibe ;

Garedew, Asnake Desalegn ;

Yifat, Fitsum Tigu ;

Birri, Dagim Jirata .

BIOMEDICINE & PHARMACOTHERAPY, 2020, 129

[7]

Begum J., 2021, Lett Anim Biol, V1, P01, DOI [10.62310/liab.v1i1.53, DOI 10.62310/LIAB.V1I1.53]

[8] The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF2α synthesis in adipocytes [J].

Belda, Benjamin J. ;

Thompson, Jerry T. ;

Sinha, Raghu ;

Prabhu, K. Sandeep ;

Vanden Heuvel, John P. .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2012, 99 (1-2) :30-37

[9]

Belury M.A., 2020, ADV CONJUGATED LINOL, P302, DOI [10.4324/9780429270703-19, DOI 10.4324/9780429270703-19]

[10] Pros and cons of CLA consumption: an insight from clinical evidences [J].

Benjamin, Sailas ;

Prakasan, Priji ;

Sreedharan, Sajith ;

Wright, Andre-Denis G. ;

Spener, Friedrich .

NUTRITION & METABOLISM, 2015, 12

← 1 2 3 4 5 6 7 8 9 10 →