Association of Biomarkers with the Severity of Depression

被引:0
作者
Agnihotri, Shruti [1 ]
Daripelly, Suresh [1 ]
Cherla, Shirley Keerthana [1 ]
Jopaka, Ajay Kumar [1 ]
Molanguri, Umashankar [1 ]
机构
[1] Gandhi Med Coll & Hosp, Dept Psychiat, Secunderabad 500003, Telangana, India
关键词
C-reactive protein; cortisol; magnesium; neutrophil-lymphocyte ratio; depression; inflammation; REACTIVE PROTEIN-LEVELS; MAJOR DEPRESSION; MAGNESIUM INTAKE; INFLAMMATION; CORTISOL; ANXIETY; MARKERS; STRESS;
D O I
10.1177/02537176241264609
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: The pathogenesis of depression remains elusive and uncertain. The literature suggests that low-grade systemic inflammation might contribute to the etiology of depression. Other markers that are studied are serum magnesium and serum cortisol. The association between these factors might help understand the etiology. Methods: This was a cross-sectional study conducted on a sample of 40 participants. Socio-demographic data was noted, and the Hamilton depression rating scale was applied to rate the severity of depression. Blood samples were drawn at 8 a.m. to record a complete blood picture (to derive the neutrophil-lymphocyte ratio (NLR)), C-reactive protein, serum magnesium, and serum cortisol. Results: In this study, conducted on a sample size of 40, inflammatory markers such as C-reactive protein (CRP: mg/dl) and NLR were significantly increased to 15.52 +/- 13.10 and 6.46 +/- 2.92, respectively, showing an underlying inflammatory pathology. Serum cortisol (mu g/dl) was also raised to 22.30 +/- 5.46, and there was a fall in serum magnesium. Also, it is noteworthy that all these markers were significantly associated with the severity of depression, as the Pearson correlation between the Hamilton depression rating scale-21 item (HAM-D-21) score and CRP, NLR, and serum cortisol was positive and statistically significant (r = 0.55, p < .01; r = 0.51, p = .01; r = 0.46, p = .002). The Pearson correlation between the HAM-D score and serum magnesium was negative and statistically significant (r = -0.82, p < .01) Conclusion: There is a state of systemic inflammation, hypercortisolemia, and hypomagnesemia in depressive disorders.
引用
收藏
页数:5
相关论文
共 50 条
[41]   The Association of Biochemical and Genetic Biomarkers in VEGF Pathway with Depression [J].
Nunes, Fernanda Daniela Dornelas ;
Ferezin, Leticia Perticarrara ;
Pereira, Sherliane Carla ;
Figaro-Drumond, Fernanda Viana ;
Pinheiro, Lucas Cezar ;
Menezes, Itiana Castro ;
Baes, Cristiane von Werne ;
Coeli-Lacchini, Fernanda Borchers ;
Tanus-Santos, Jose Eduardo ;
Juruena, Mario Francisco ;
Lacchini, Riccardo .
PHARMACEUTICS, 2022, 14 (12)
[42]   Potential Biomarkers for Predicting Depression in Diabetes Mellitus [J].
Song, Xiuli ;
Zheng, Qiang ;
Zhang, Rui ;
Wang, Miye ;
Deng, Wei ;
Wang, Qiang ;
Guo, Wanjun ;
Li, Tao ;
Ma, Xiaohong .
FRONTIERS IN PSYCHIATRY, 2021, 12
[43]   Potential biomarkers of major depression diagnosis and chronicity [J].
de Menezes Galvao, Ana Cecilia ;
Almeida, Raissa Nobrega ;
de Sousa Junior, Geovan Menezes ;
Leocadio-Miguel, Mario Andre ;
Palhano-Fontes, Fernanda ;
de Araujo, Draulio Barros ;
Lobao-Soares, Bruno ;
Maia-de-Oliveira, Joao Paulo ;
Nunes, Emerson Arcoverde ;
Cecilio Hallak, Jaime Eduardo ;
Sarris, Jerome ;
Galvao-Coelho, Nicole Leite .
PLOS ONE, 2021, 16 (09)
[44]   SuPAR in major depression: Association with 26 weeks antidepressant response and 10-year depression outcomes [J].
Haupt, T. H. ;
Elfving, B. ;
Eugen-Olsen, J. ;
Mors, O. ;
Kohler-Forsberg, O. .
BRAIN BEHAVIOR & IMMUNITY-HEALTH, 2023, 33
[45]   DEPRESSION, FAMILY AND IMMUNITY: INFLUENCE OF HUMORAL IMMUNITY ON FAMILY RELATIONSHIPS AND ON THE SEVERITY OF DEPRESSION [J].
Dubois, Thomas ;
Zdanowicz, Nicolas ;
Reynaert, Christine ;
Jacques, Denis .
PSYCHIATRIA DANUBINA, 2016, 28 :S170-S174
[46]   Relationships of neutrophil-lymphocyte and platelet-lymphocyte ratios with the severity of major depression [J].
Kayhan, Fatih ;
Gunduz, S. Sule ;
Ersoy, Sevde Afife ;
Kandeger, Ali ;
Annagur, Bilge Burcak .
PSYCHIATRY RESEARCH, 2017, 247 :332-335
[47]   Biological Sex and IgE Sensitization Influence Severity of Depression and Cortisol Levels in Atopic Dermatitis [J].
Vinnik, Tatyana ;
Kreinin, Anatoly ;
Abildinova, Gulshara ;
Batpenova, Gulnar ;
Kirby, Michael ;
Pinhasov, Albert .
DERMATOLOGY, 2020, 236 (04) :336-344
[48]   Department of Clinical Nutrition, College of Applied Medical Sciences, Umm Al-Qura Association between Depression Levels and Body Weight and Dietary Habits in a Sample of the Saudi Population: A Cross-Sectional Study [J].
Alyamani, Reema Abdulrahman Saad ;
Alhussieni, Jawaher Ahmed Abdullah ;
Alghash-Mari, Muruj Matuq Mansi ;
Alkhozai, Raghad Muslim Salem ;
Alsulami, Renad Ayyad Owaid ;
Sab, Shaima Zaki Mahmoud ;
Alamri, Reham Abdullah Ali ;
Almuraee, Areej Abdulhamid Hamdan ;
Bakr, El-Sayed Hamed Ali ;
Qadhi, Alaa Hatim Hassan ;
Alhassani, Walaa Essam Mohammed ;
Alkholy, Sarah Omar Fathi ;
Azzeh, Firas Sultan Ibrahim ;
Almehmadi, Awatif Musallam Salem ;
Awlya, Ohaad Fahd Abdulaziz .
CURRENT RESEARCH IN NUTRITION AND FOOD SCIENCE, 2024, 12 (02) :591-601
[49]   Inflammatory Biomarkers and Depression [J].
Norbert Müller ;
Aye-Mu Myint ;
Markus J. Schwarz .
Neurotoxicity Research, 2011, 19 :308-318
[50]   Stress, inflammation, depression, and dementia associated with phosphate toxicity [J].
Brown, Ronald B. .
MOLECULAR BIOLOGY REPORTS, 2020, 47 (12) :9921-9929