Cross-sectional association between high-sensitivity C-reactive protein and cognitive function in community-dwelling older adults: the SONIC study

被引：1

作者：

Hosokawa, Mariko ^{[1
]}

Kabayama, Mai ^{[1
]}

Godai, Kayo ^{[1
]}

Akagi, Yuya ^{[1
]}

Tachibana, Yuka ^{[1
]}

Gondo, Yasuyuki ^{[2
]}

Yasumoto, Saori ^{[3
]}

Masui, Yukie ^{[4
]}

Hirata, Takumi ^{[4
]}

Ishizaki, Tatsuro ^{[4
]}

Akasaka, Hiroshi ^{[5
]}

Takeya, Yasushi ^{[1
,5
]}

Takami, Yoichi ^{[5
]}

Yamamoto, Koichi ^{[5
]}

Kitamura, Masahiro ^{[6
]}

Ikebe, Kazunori ^{[7
]}

Arai, Yasumichi ^{[8
]}

Rakugi, Hiromi ^{[5
]}

Kamide, Kei ^{[1
,5
]}

机构：

[1] Osaka Univ, Grad Sch Med, Div Hlth Sci, 1-7 Yamada Oka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Human Sci, Dept Clin Thanatol & Geriatr Behav Sci, Osaka, Japan

[3] Osaka Univ, Grad Sch Human Sci, Off Int Exchange, Osaka, Japan

[4] Tokyo Metropolitan Inst Geriatr & Gerontol, Tokyo, Japan

[5] Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Osaka, Japan

[6] Osaka Univ, Grad Sch Dent, Dept Periodontol & Regenerat Dent, Osaka, Japan

[7] Osaka Univ, Grad Sch Dent, Dept Removable Prosthodont & Gerodontol, Osaka, Japan

[8] Keio Univ, Sch Med, Ctr Supercentenarian Med Res, Tokyo, Japan

来源：

BMC GERIATRICS | 2024年 / 24卷 / 01期

关键词：

Cognitive impairment; MoCA-J; High-sensitivity C-reactive protein; Chronic inflammation; Epidemiologic study in general population; BRIEF SCREENING TOOL; DEMENTIA; RISK; INFLAMMATION; DISEASE; THICKNESS; JAPANESE; MARKERS;

D O I：

10.1186/s12877-024-05354-x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BackgroundA decline in cognitive function is associated with inflammatory processes. However, the association between high-sensitivity C-reactive protein (hs-CRP) levels and cognitive decline in the Japanese population remains inconclusive. Thus, this study aimed to determine whether hs-CRP is associated with low cognitive function in 70- and 80-year-old community-dwelling Japanese individuals.MethodsThe participants in this cross-sectional study were 872 Japanese residents aged 70 and 80 years who voluntarily participated in the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study between 2010 and 2011. Blood sample collection, cognitive assessment, and other measurements were performed at the venue. Low cognitive function was defined as a score of 25 points or lower on the Japanese version of the Montreal Cognitive Assessment. The odds ratio (OR) and 95% confidence interval (95% CI) for each hs-CRP quartile were calculated using logistic regression analysis.ResultsA total of 288 (69.9%) parsons in the 70-year-old group and 372 (80.9%) in the 80-year-old group exhibited low cognitive function. The association between hs-CRP levels and low cognitive function was significant among 70- and 80-year-old Japanese community-dwelling adults. In particular, the fourth quartile of hs-CRP (0.727-7.420 mg/L) in the 70-year-old group and the second and fourth quartiles (0.214-0.404 and 0.911-9.890 mg/L) in the 80-year-old group were associated with low cognitive function. Furthermore, the third quartile (0.409-0.892 mg/L) in the 80-year-old group was closely associated with low cognitive function.ConclusionsHigh hs-CRP levels were associated with lower cognitive function in 70- and 80-year-old Japanese community-dwelling individuals, suggesting that high hs-CRP levels may influence cognitive function.

引用

页数：8

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