Concise synthesis of pyridopyridazines

被引：0

作者：

Zheng, Xiaoyan ^{[1
]}

Ke, Congyu ^{[1
,3
]}

Wang, Sichang ^{[1
,3
]}

Huang, Shenlin ^{[2
]}

机构：

[1] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China

[2] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China

[3] Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China

来源：

TETRAHEDRON LETTERS | 2024年 / 149卷

关键词：

Pd(II)-catalyzed; 3,5-dichloropyridazine; Selective Suzuki monocoupling; Buchwald coupling; Intramolecular cyclization;

D O I：

10.1016/j.tetlet.2024.155263

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and concise method is hereby reported for the synthesis of pyrido[3,4-c]pyridazin-8(7H)-ones c ]pyridazin-8(7H)-ones from the commercially available material, methyl 4,6-dichloropyridazine-3-carboxylate. The four-step reaction process involves Suzuki coupling, Buchwald coupling, ammoniation, and intramolecular cyclization. The advantage of this route represents the development of a novel C5 site-selective Suzuki monocoupling of 3,5-dichloropyridazine, with an overall yield of over 73 %.

引用

页数：4

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