Concise synthesis of pyridopyridazines

被引：0
|
作者：
Zheng, Xiaoyan [1 ]
Ke, Congyu [1 ,3 ]
Wang, Sichang [1 ,3 ]
Huang, Shenlin [2 ]
机构：
[1] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China
[2] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China
[3] Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China
来源：
TETRAHEDRON LETTERS | 2024年 / 149卷
关键词：
Pd(II)-catalyzed; 3,5-dichloropyridazine; Selective Suzuki monocoupling; Buchwald coupling; Intramolecular cyclization;
D O I：
10.1016/j.tetlet.2024.155263
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and concise method is hereby reported for the synthesis of pyrido[3,4-c]pyridazin-8(7H)-ones c ]pyridazin-8(7H)-ones from the commercially available material, methyl 4,6-dichloropyridazine-3-carboxylate. The four-step reaction process involves Suzuki coupling, Buchwald coupling, ammoniation, and intramolecular cyclization. The advantage of this route represents the development of a novel C5 site-selective Suzuki monocoupling of 3,5-dichloropyridazine, with an overall yield of over 73 %.
引用
收藏
页数：4
相关论文
共 50 条
  • [21] A Concise Synthesis of Forskolin
    Hylse, Ondrej
    Maier, Lukas
    Kucera, Roman
    Perecko, Tomas
    Svobodova, Aneta
    Kubala, Lukas
    Paruch, Kamil
    Svenda, Jakub
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (41) : 12586 - 12589
  • [22] A concise synthesis of tashiromine
    McElhinney, AD
    Marsden, SP
    SYNLETT, 2005, (16) : 2528 - 2530
  • [23] Concise Synthesis of Norrisolide
    Granger, Krista
    Snapper, Marc L.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (12) : 2308 - 2311
  • [24] A CONCISE SYNTHESIS OF (+/-)-PEROVSKONE
    MAJETICH, G
    YONG, Z
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 43 - ORGN
  • [25] Concise Synthesis of Goniothalesdiol A
    Zeng, Ping Li
    Zhou, Junhui
    Yang, Xuechao
    Wang, Dong
    Dong, Zhibing
    LETTERS IN ORGANIC CHEMISTRY, 2022, 19 (12) : 1145 - 1148
  • [26] A concise synthesis of (-)-oseltamivir
    Trost, Barry M.
    Zhang, Ting
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (20) : 3759 - 3761
  • [27] CONCISE SYNTHESIS OF (±)-AURANTIOCLAVINE
    Ikota, Hideo
    Tsukano, Chihiro
    Takemoto, Yoshiji
    HETEROCYCLES, 2018, 97 (01) : 621 - 631
  • [28] A CONCISE SYNTHESIS OF HYDROXYBUFURALOL
    COLLIER, P
    SCHEINMANN, F
    STACHULSKI, AV
    JOURNAL OF CHEMICAL RESEARCH-S, 1994, (08): : 312 - 313
  • [29] A Concise Synthesis of Carolacton
    Hallside, Michal S.
    Brzozowski, Richard S.
    Wuest, William M.
    Phillips, Andrew J.
    ORGANIC LETTERS, 2014, 16 (04) : 1148 - 1151
  • [30] Concise synthesis of (+)-serinolamide A
    Gao, Ya-Ru
    Guo, Shi-Huan
    Zhang, Zhuan-Xiang
    Mao, Shuai
    Zhang, Yan-Lei
    Wang, Yong-Qiang
    TETRAHEDRON LETTERS, 2013, 54 (48) : 6511 - 6513
12345