Concise synthesis of pyridopyridazines

被引：0
|
作者：
Zheng, Xiaoyan [1 ]
Ke, Congyu [1 ,3 ]
Wang, Sichang [1 ,3 ]
Huang, Shenlin [2 ]
机构：
[1] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China
[2] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China
[3] Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China
来源：
TETRAHEDRON LETTERS | 2024年 / 149卷
关键词：
Pd(II)-catalyzed; 3,5-dichloropyridazine; Selective Suzuki monocoupling; Buchwald coupling; Intramolecular cyclization;
D O I：
10.1016/j.tetlet.2024.155263
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and concise method is hereby reported for the synthesis of pyrido[3,4-c]pyridazin-8(7H)-ones c ]pyridazin-8(7H)-ones from the commercially available material, methyl 4,6-dichloropyridazine-3-carboxylate. The four-step reaction process involves Suzuki coupling, Buchwald coupling, ammoniation, and intramolecular cyclization. The advantage of this route represents the development of a novel C5 site-selective Suzuki monocoupling of 3,5-dichloropyridazine, with an overall yield of over 73 %.
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页数：4
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