Facile preparation of metal organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment

被引：74
作者：
Dong, Kai [1 ,2 ]
Zhang, Yan [1 ,2 ,3 ]
Zhang, Lu [1 ,2 ,4 ]
Wang, Zhenzhen [1 ,2 ,3 ]
Ren, Jinsong [1 ,2 ]
Qu, Xiaogang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[4] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
TALANTA | 2019年 / 194卷
基金：
中国国家自然科学基金;
关键词：
Metal-organic frameworks; Hydrophobic drug; Targeting; Cancer therapy; MESOPOROUS SILICA NANOPARTICLES; SYNERGISTIC THERAPY; PH; RELEASE; POLYMER; SYSTEM; NANOCARRIERS; PLATFORM; STORAGE; MOF;
D O I：
10.1016/j.talanta.2018.10.101
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Nowadays, cancer has been one of the major threats to human beings throughout the world. Nanomedicines have been demonstrated as a promising candidate for cancer chemotherapy. In this work, we facilely constructed a RGD (Arg-Gly-Asp) modified camptothecin@zeolitic imidazolate framework-8 (RGD@CPT@ZIF-8) as a novel metal-organic frameworks-based hydrophobic drug delivery system for targeted and enhanced cancer treatment. In our system, the nanoplatform exhibited the superior property of target to the cancer cells due to the function with RGD. More importantly, the RGD@CPT@ZIF-8 nanoplatform has shown the enhanced cancer cell treatment due to the excellent pH-responsive hydrophobic anticancer drug delivery and intracellular ROS generation. With the excellent targeting and enhanced therapy performance, we envision that the hydrophobic anticancer drug delivery system could become a potential therapeutic agent for targeted cancer treatment.
引用
收藏
页码：703 / 708
页数：6
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