Extracellular vesicles as carriers for mitochondria: Biological functions and clinical applications

被引:0
|
作者
Liao, Zhiwei [1 ]
Tong, Bide [1 ]
Ke, Wencan [1 ]
Yang, Cao [1 ]
Wu, Xinghuo [1 ]
Lei, Ming [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan 430022, Peoples R China
基金
中国国家自然科学基金;
关键词
Extracellular vesicles; Mitochondrial transfer; Mitochondria-derived vesicles; Mitochondrial quality control; CELLULAR UPTAKE; STROMAL CELLS; IN-VITRO; EXOSOMES; SECRETION; DISEASE; VIVO; DNA; CARDIOMYOCYTES; INFLAMMATION;
D O I
10.1016/j.mito.2024.101935
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In recent years, research has increasingly focused on the biogenesis of extracellular vesicles (EVs) and the sorting mechanisms for their contents. Mitochondria can be selectively loaded into EVs, serving as a way to maintain cellular mitochondrial homeostasis. EV-mediated mitochondrial transfer has also been shown to greatly impact the function of target cells. Based on the mechanism of EV-mediated mitochondrial transfer, therapies can be developed to treat human diseases. This review summarizes the recent advances in the biogenesis and molecular composition of EVs. It also highlights the sorting and trafficking mechanisms of mitochondrial components into EVs. Furthermore, it explores the current role of EV-mediated mitochondrial transfer in the development of human diseases, as well as its diagnostic and therapeutic applications.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Trends in the biological functions and medical applications of extracellular vesicles and analogues
    Yan Zhao
    Xiaolu Li
    Wenbo Zhang
    Lanlan Yu
    Yang Wang
    Zhun Deng
    Mingwei Liu
    Shanshan Mo
    Ruonan Wang
    Jinming Zhao
    Shuli Liu
    Yun Hao
    Xiangdong Wang
    Tianjiao Ji
    Luo Zhang
    Chenxuan Wang
    Acta Pharmaceutica Sinica B, 2021, 11 (08) : 2114 - 2135
  • [2] Trends in the biological functions and medical applications of extracellular vesicles and analogues
    Zhao, Yan
    Li, Xiaolu
    Zhang, Wenbo
    Yu, Lanlan
    Wang, Yang
    Deng, Zhun
    Liu, Mingwei
    Mo, Shanshan
    Wang, Ruonan
    Zhao, Jinming
    Liu, Shuli
    Hao, Yun
    Wang, Xiangdong
    Ji, Tianjiao
    Zhang, Luo
    Wang, Chenxuan
    ACTA PHARMACEUTICA SINICA B, 2021, 11 (08) : 2114 - 2135
  • [3] Biological functions and biomedical applications of extracellular vesicles derived from blood cells
    Pan, Kaifeng
    Zhu, Yiwei
    Chen, Pengyu
    Yang, Ke
    Chen, Yiyu
    Wang, Yongcheng
    Dai, Zhanqiu
    Huang, Zhenxiang
    Zhong, Peiyu
    Zhao, Xing
    Fan, Shunwu
    Ning, Lei
    Zhang, Jianfeng
    Chen, Pengfei
    FREE RADICAL BIOLOGY AND MEDICINE, 2024, 222 : 43 - 61
  • [4] Overview of the interaction of helminth extracellular vesicles with the host and their potential functions and biological applications
    Sanchez-Lopez, Christian M.
    Trelis, Maria
    Bernal, Dolores
    Marcilla, Antonio
    MOLECULAR IMMUNOLOGY, 2021, 134 : 228 - 235
  • [5] Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
    Wang, Yi
    Zhao, Ruichen
    Jiao, Xueqiao
    Wu, Longyuan
    Wei, Yuxuan
    Shi, Fuxiu
    Zhong, Junpei
    Xiong, Lixia
    LIFE-BASEL, 2021, 11 (10):
  • [6] Biological properties of extracellular vesicles and their physiological functions
    Yanez-Mo, Maria
    Siljander, Pia R. -M.
    Andreu, Zoraida
    Zavec, Apolonija Bedina
    Borras, Francesc E.
    Buzas, Edit I.
    Buzas, Krisztina
    Casal, Enriqueta
    Cappello, Francesco
    Carvalho, Joana
    Colas, Eva
    Cordeiro-da Silva, Anabela
    Fais, Stefano
    Falcon-Perez, Juan M.
    Ghobrial, Irene M.
    Giebel, Bernd
    Gimona, Mario
    Graner, Michael
    Gursel, Ihsan
    Gursel, Mayda
    Heegaard, Niels H. H.
    Hendrix, An
    Kierulf, Peter
    Kokubun, Katsutoshi
    Kosanovic, Maja
    Kralj-Iglic, Veronika
    Kraemer-Albers, Eva-Maria
    Laitinen, Saara
    Lasser, Cecilia
    Lener, Thomas
    Ligeti, Erzsebet
    Line, Aija
    Lipps, Georg
    Llorente, Alicia
    Lotvall, Jan
    Mancek-Keber, Mateja
    Marcilla, Antonio
    Mittelbrunn, Maria
    Nazarenko, Irina
    Nolte-t' Hoen, Esther N. M.
    Nyman, Tuula A.
    O'Driscoll, Lorraine
    Olivan, Mireia
    Oliveira, Carla
    Pallinger, Eva
    del Portillo, Hernando A.
    Reventos, Jaume
    Rigau, Marina
    Rohde, Eva
    Sammar, Marei
    JOURNAL OF EXTRACELLULAR VESICLES, 2015, 4 : 1 - 60
  • [7] Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives
    Raimondo, Stefania
    Pucci, Marzia
    Alessandro, Riccardo
    Fontana, Simona
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (07)
  • [8] Extracellular vesicles in the breast cancer brain metastasis: physiological functions and clinical applications
    Sakamoto, Yuima
    Ochiya, Takahiro
    Yoshioka, Yusuke
    FRONTIERS IN HUMAN NEUROSCIENCE, 2023, 17
  • [9] Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
    Hu, Miao
    Li, Juan
    Liu, Chen-Guang
    Goh, Robby Miguel W. J.
    Yu, Fenggang
    Ma, Zhaowu
    Wang, Lingzhi
    CELLS, 2022, 11 (06)
  • [10] Biological functions of extracellular vesicles from mammalian cells
    Kanellopoulos, Jean M.
    Rieux-Laucat, Frederic
    Ojcius, David M.
    BIOMEDICAL JOURNAL, 2024, 47 (05)