Determining the Best Noninvasive Test for Peripheral Arterial Disease Diagnosis to Predict Diabetic Foot Ulcer Healing in Patients Following Endovascular Revascularization

被引:0
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作者
Alvaro-Afonso, Francisco Javier [1 ]
Garcia-Alvarez, Yolanda [1 ]
Garcia-Morales, Esther Alicia [1 ]
Flores-Escobar, Sebastian [1 ]
De Benito-Fernandez, Luis [2 ]
Alfayate-Garcia, Jesus [2 ]
Sanchez-Rios, Juan Pedro [2 ]
Puras-Mallagray, Enrique [3 ,4 ]
Malo-Benages, Esteban Javier [3 ]
Ramirez-Ortega, Marta [4 ]
Redondo-Lopez, Sandra [5 ]
Cecilia-Matilla, Almudena [6 ]
Lazaro-Martinez, Jose Luis [1 ]
机构
[1] Univ Complutense Madrid, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Fac Enfermeria Fisioterapia & Podol, Diabetic Foot Unit,Clin Univ Podol, Madrid 28040, Spain
[2] Hosp Univ Fdn Alcorcon, Angiol & Vasc Dept, Diabetic Foot Unit, Alcorcon 28922, Spain
[3] Hosp Univ Quironsalud Madrid, Angiol Vasc & Endovasc Dept, Pozuelo De Alarcon 28223, Spain
[4] Hosp Univ La Luz, Angiol Vasc & Endovascular Dept, Grp Quironsalud, Madrid 28003, Spain
[5] Ruber Int Hosp Madrid, Vasc Surg Serv, C-Maso 38, Madrid 28034, Spain
[6] Hosp Univ Ramon & Cajal, Vasc Surg Serv, Diabetic Foot Unit, Inst Ramon & Cajal Invest Sanitaria IRYCIS Crta, Colmenar Viejo Km 9100, Madrid 28034, Spain
关键词
diabetic foot; diabetic foot ulcer; diagnosis; peripheral arterial disease; endovascular revascularization; RISK; INFECTION;
D O I
10.3390/healthcare12161664
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background/Objectives: To analyze the best noninvasive tests prognosis marker in patients with diabetic foot ulcer (DFU) who underwent endovascular revascularization based on clinical outcomes, such as healing rate, time to heal, and free amputation survival after at least a six-month follow-up. Methods: A multicentric prospective observational study was performed with 28 participants with ischemic or neuroischemic DFU who came to the participant centers and underwent endovascular revascularization between January 2022 and March 2023. Toe systolic pressure (TP), ankle systolic pressure (AP), the ankle brachial pressure index (ABPI), the toe brachial pressure index (TBPI), transcutaneous pressure of oxygen (TcPO2), and skin perfusion pressure (SPP) were evaluated using PeriFlux 6000 System, Perimed, Sweden, before (Visit 0) and four weeks after revascularization (Visit 1). The primary clinical outcome was an evaluation of the clinical evolution of noninvasive tests comparing Visit 0 and Visit 1, estimating the sensitivity for predicting wound healing of noninvasive tests at six months following initial recruitment. Results: After six months, 71.43% (n = 20) of DFU healed, four patients (14.3%) received major amputations, and one (3.5%) died. The two tests that best predicted wound healing after revascularization according to the ROC curve were TcPO2 and TP with sensitivities of 0.89 and 0.70 for the cut-off points of 24 mmHg and 46 mmHg, respectively. Conclusions: TcPO2 and TP were the two tests that best predicted wound healing in patients who underwent endovascular revascularization. Clinicians should consider the importance of the evaluation of microcirculation in the healing prognosis of patients with diabetic foot ulcers.
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页数:12
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