Sustained Antibiotic Release from Biodegradable Gelatin-Silica Hybrid for Orthopedic Infections

被引:1
|
作者
Lin, Yu-Chien [1 ,2 ]
Lee, Chin-Yun [1 ]
Jones, Julian R. [3 ]
Liu, Wai-Ching [4 ]
Cho, Nam-Joon [2 ,5 ]
Hu, Chih-Chien [6 ,7 ,8 ]
Chung, Ren-Jei [1 ,9 ]
机构
[1] Natl Taipei Univ Technol, Dept Chem Engn & Biotechnol, Taipei 10608, Taiwan
[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore
[3] Imperial Coll London, Dept Mat, London SW7 2BP, England
[4] Technol & Higher Educ Inst Hong Kong, Dept Food & Hlth Sci, Hong Kong, Peoples R China
[5] Nanyang Technol Univ, Ctr Cross Econ Global, Singapore 637553, Singapore
[6] Chang Gung Mem Hosp, Bone & Joint Res Ctr, Taoyuan 333, Taiwan
[7] Chang Gung Mem Hosp, Dept Orthopaed Surg, Taoyuan 333, Taiwan
[8] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan
[9] Natl Taipei Univ Technol, High Value Biomat Res & Commercializat Ctr, Taipei 10608, Taiwan
关键词
antibacterial activity; biodegradable; bone filler; gelatin-silica hybrid; long-term antibiotic release; BIOACTIVE-GLASS; REGENERATION; REVISION; HIP;
D O I
10.1002/adfm.202409491
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Antibiotic-loaded polymethylmethacrylate (PMMA) beads are commonly employed to treat prosthetic joint infections (PJI) and chronic osteomyelitis due to their excellent mechanical strength. However, PMMA's non-degradability results in a burst release of antibiotics and potential renal toxicity, necessitating additional surgeries for bead removal. There is a critical need for infection control materials that can deliver antibiotics effectively, maintain adequate mechanical strength, and degrade uniformly. This study introduces a gelatin-silica hybrid antibiotic carrier, characterized by covalent bonds between the gelatin and silica networks. The incorporation of the silica network enhances the compressive strength to 32.53 +/- 2.4 MPa and ensures uniform degradation over 6 months, aligning with clinical timelines. Furthermore, the gelatin-silica hybrid can support up to 10 wt% antibiotic loading without compromising its properties, making it a promising candidate for next-generation infection control materials. A gelatin-silica hybrid is developed as a carrier to facilitate controlled degradation and ensure the sustained, homogeneous release of antibiotics. Concurrently, it offers exceptional mechanical properties for the management of orthopedic infections. image
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页数:14
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