Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing

Skin wound healing is an important aspect of regenerative medicine. Metal-organic frameworks (MOFs) have attracted considerable attention as promising nanomaterials for skin wound healing due to their remarkable versatility, tunable pore size, surface area, targeted delivery of various therapeutic agents, and controlled release properties. The combination of these materials with biocompatible and synthetic polymers can help improve their performance in wound regeneration. This review examines the potential of MOF-polymer composites in skin wound healing. Physical and biological chemical properties and methods of making MOFs and their composites have been investigated. In the final section of this review, challenges and future prospects for the development of MOF-polymer composites are stated. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.