Tobacco Smoking Interacted with Alcohol Drinking Could Increase the Failure of PASI75 Achievement at Week 8 Among Patients with Psoriasis: Findings Based on a Psoriasis Cohort

被引：0

作者：

Shen, Fanlingzi ^{[1
,2
]}

Song, Yu ^{[3
]}

Qiang, Yan ^{[1
]}

Gao, Xiangjin ^{[1
]}

Li, Siyuan ^{[2
]}

Zhang, Rui ^{[1
]}

Gao, Zhongzhi ^{[1
]}

Li, Bin ^{[1
]}

Jiang, Wencheng ^{[4
]}

Wang, Ruiping ^{[1
,2
]}

机构：

[1] Tongji Univ, Shanghai Skin Dis Hosp, Clin Res Ctr, Sch Med, Shanghai, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Sch Publ Hlth, Shanghai, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Dermatol, Shanghai, Peoples R China

[4] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, Dept Tradit Chinese Med, 1278 Baode Rd, Shanghai 200443, Peoples R China

来源：

PSORIASIS-TARGETS AND THERAPY | 2024年 / 14卷

关键词：

psoriasis; tobacco smoking; alcohol drinking; interaction; additive model; multiplicative model; CONSUMPTION; EFFICACY;

D O I：

10.2147/PTT.S484609

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Purpose: Tobacco smoking and alcohol drinking are positively associated with psoriasis prevalence and disease severity. Researches focusing on the influence of smoking and drinking on the treatment efficacy of psoriasis are still limited, especially their interaction effect. This study aims to explore the interactive effects of smoking and drinking on the treatment efficacy in psoriasis patients. Patients and Methods: From 2021 to 2022, we recruited 560 patients with psoriasis from Shanghai Skin Diseases Hospital. Demographic and clinical features as well as treatment efficacy were collected through questionnaire interview and physical examination during patient's hospital visit at week 0, week 4 and week 8. Logistic regression model was used to explore the influence of smoking and drinking on the treatment efficacy in psoriasis patients, and multiplicative and additive interaction models were used to verify the interaction effect of smoking and drinking on the treatment efficacy. Results: The prevalence of smoking and drinking among psoriasis patients was respectively 43.8% and 25.4%, and 19.6% of them with both smoking and drinking. Logistic regression analysis showed that patients with smoking (OR=7.78, 95% CI: 5.26 similar to 11.49) and drinking (OR=5.21, 95% CI: 3.29 similar to 8.27) had higher risk of experiencing the failure to achieve PASI(75) at week 8, even with the adjustment of confounders. Moreover, multiplicative as well as additive model showed that tobacco smoking interacted with alcohol drinking which influenced the treatment efficacy more severely (OR=12.74, 95% CI: 7.16 similar to 22.67). The proportion of PASI(75) achievement in female patients (OR=19.54) and patients with methotrexate (OR=28.31) and biologics (OR=21.61) were more likely being affected by smoking and drinking. Conclusion: Tobacco smoking and alcohol drinking could increase the failure of PASI(75) achievement in patients with psoriasis, individually and interactively. We recommend that dermatologists should educate patients to pay attention to the negative effects of smoking and drinking, encourage them to quit, and thus improve the treatment efficacy.

引用

页码：103 / 114

页数：12