Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

被引：0

作者：

Yun, Minsik ^{[1
]}

Kim, Do-Hyoung ^{[1
]}

Ha, Tal Soo ^{[2
]}

Lee, Kang-Min ^{[1
]}

Park, Eungyu ^{[1
]}

Knaden, Markus ^{[3
,4
]}

Hansson, Bill S. ^{[3
,4
]}

Kim, Young-Joon ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol GIST, Sch Life Sci, Gwangju, South Korea

[2] Daegu Univ, Coll Nat Sci, Dept Biomed Sci, Gyoungsan, South Korea

[3] Max Planck Inst Chem Ecol, Dept Evolutionary Neuroethol, Jena, Germany

[4] Max Planck Inst Chem Ecol, Max Planck Ctr, Next Generat Insect Chem Ecol, Jena, Germany

来源：

ELIFE | 2024年 / 13卷

基金：

新加坡国家研究基金会;

关键词：

sperm ejection; mating; pC1; Or47b; ppk23; sexual plasticity; BEHAVIORAL-RESPONSES; SPERM COMPETITION; CHEMORECEPTORS; TEMPERATURE; ATTRACTION; EXPRESSION; PREGNANCY; EJECTION; RECEPTOR; BLOCK;

D O I：

10.7554/eLife.96013

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In birds and insects, the female uptakes sperm for a specific duration post-copulation known as the ejaculate holding period (EHP) before expelling unused sperm and the mating plug through sperm ejection. In this study, we found that Drosophila melanogaster females shortens the EHP when incubated with males or mated females shortly after the first mating. This phenomenon, which we termed male-induced EHP shortening (MIES), requires Or47b+ olfactory and ppk23+ gustatory neurons, activated by 2-methyltetracosane and 7-tricosene, respectively. These odorants raise cAMP levels in pC1 neurons, responsible for processing male courtship cues and regulating female mating receptivity. Elevated cAMP levels in pC1 neurons reduce EHP and reinstate their responsiveness to male courtship cues, promoting re-mating with faster sperm ejection. This study established MIES as a genetically tractable model of sexual plasticity with a conserved neural mechanism.

引用

页数：27