Optimizing sexual reproductive health of men and women with cystic fibrosis: A systematic review

被引：0

作者：

Iyer, Anand G. ^{[1
]}

Yu, Benjamin ^{[2
]}

Reddy, Amit ^{[2
]}

Khera, Mohit ^{[2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[2] Baylor Coll Med, Dept Urol, 2457 S Braeswood Blvd, Houston, TX 77030 USA

来源：

JOURNAL OF CYSTIC FIBROSIS | 2024年 / 23卷 / 04期

关键词：

Sexual reproductive health; CF; Pubertal development; Phe508del; CBAVD; ART; CONGENITAL BILATERAL ABSENCE; TRANSMEMBRANE REGULATOR; SPERM RETRIEVAL; CFTR MUTATIONS; PREGNANCY; FERTILITY; CHILDREN; OUTCOMES;

D O I：

10.1016/j.jcf.2024.01.009

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

This systematic review summarizes the impact of cystic fibrosis (CF) on sexual and reproductive health (SRH) in males and females, covering pubertal development, hormonal function, family planning, and fertility. Included articles featured historical CF diagnostic criteria, preclinical or clinical data (retrospective cohorts or open label trials), while excluded articles lacked full text availability, explicit methodology, or comparisons between CF and non-CF patients. Genotype differences in CFTR mutations influenced symptom severity. Males with CF experienced delayed puberty, hypogonadism, infertility from obstructive azoospermia, and semen parameter issues. Female CF patients showed decreased fertility, possibly linked to disrupted ionic balance and ovarian cystic disease. Assistive reproductive technologies addressed fertility issues, but success varied based on disease severity and genotype. CFTR modulators aided pulmonary function and sexual health but require further assessment for fertility benefits.

引用

页码：633 / 638

页数：6

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