Surgical treatment of lung cancer associated with Werner's syndrome: A case report and review of the literature

被引：0

作者：

Ishibashi, Fumihiro ^{[1
,2
]}

Horio, Joji ^{[1
]}

Tachibana, Kaori ^{[3
]}

Terada, Jiro ^{[4
]}

Shibuya, Kiyoshi ^{[1
,2
]}

机构：

[1] Japanese Red Cross Narita Hosp, Dept Chest Surg, 90-1 Iida cho, Narita, Chiba 2868523, Japan

[2] Chiba Univ Hosp, Japanese Red Cross Narita Hosp, Lung Canc Treatment Ctr, Narita, Japan

[3] Japanese Red Cross Narita Hosp, Dept Diabet Metab Dis Endocrinol, Narita, Japan

[4] Japanese Red Cross Narita Hosp, Dept Resp Med, Narita, Japan

来源：

RESPIROLOGY CASE REPORTS | 2024年 / 12卷 / 09期

关键词：

complications; lung cancer; progeria; surgery; Werner's syndrome;

D O I：

10.1002/rcr2.70018

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Werner's syndrome is a rare progressive disorder that is characterized by a variety of clinical manifestations which mimic features of advanced ageing. Malignancy is one of the most problematic complications of Werner's syndrome. Lung cancer associated with Werner's syndrome is rare. A 54-year-old woman with Werner's syndrome was referred to our department because an abnormal shadow had been detected on routine chest radiography. Chest computed tomography revealed an abnormal nodule in the left upper lobe. Bronchoscopic examination revealed the presence of squamous cell carcinoma. Other imaging studies showed no metastatic lesions; therefore, the patient was diagnosed with stage IA3 squamous cell carcinoma. She underwent left upper lobectomy and lymph node dissection without major complications, and no recurrence was found for 2 years postoperatively.

引用

页数：4

共 12 条

[1] Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2 [J].

Edwards, Deanna N. ;

Orren, David K. ;

Machwe, Amrita .

NUCLEIC ACIDS RESEARCH, 2014, 42 (12) :7748-7761

[2]

Goto M, 1996, CANCER EPIDEM BIOMAR, V5, P239

[3] Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing [J].

Goto, M .

MECHANISMS OF AGEING AND DEVELOPMENT, 1997, 98 (03) :239-254

[4] Combination immunotherapy of nivolumab plus ipilimumab in a lung cancer patient with Werner syndrome; a case report [J].

Ikematsu, Yuki ;

Izumi, Miiru ;

Katahira, Katsuyuki ;

Ueno, Tsuyoshi ;

Moriuchi, Yuki ;

Ose, Mizuko ;

Noda, Naotaka ;

Hara, Makiko ;

Otsuka, Junji ;

Wakamatsu, Kentaro ;

Kawasaki, Masayuki .

RESPIRATORY MEDICINE CASE REPORTS, 2022, 37

[5] Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 2020 [J].

Kato, Hisaya ;

Koshizaka, Masaya ;

Kaneko, Hiyori ;

Maezawa, Yoshiro ;

Yokote, Koutaro .

ORPHANET JOURNAL OF RARE DISEASES, 2022, 17 (01)

[6]

Koshizaka M, 2020, AGING-US, V12, P24940, DOI 10.18632/aging.202441

[7] Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: Genetic epidemiology in the Japanese population [J].

Matsumoto, T ;

Imamura, O ;

Yamabe, Y ;

Kuromitsu, J ;

Tokutake, Y ;

Shimamoto, A ;

Suzuki, N ;

Satoh, M ;

Kitao, S ;

Ichikawa, K ;

Kataoka, H ;

Sugawara, K ;

Thomas, W ;

Mason, B ;

Tsuchihashi, Z ;

Drayna, D ;

Sugawara, M ;

Sugimoto, M ;

Furuichi, Y ;

Goto, M .

HUMAN GENETICS, 1997, 100 (01) :123-130

[8]

Naramoto A., 1992, Roka to Shikkan, V5, P1828

[9] Primary lung cancer associated with Werner syndrome [J].

Ohnishi, Shunichiro ;

Fujimoto, Masaki ;

Oide, Takashi ;

Nakatani, Yukio ;

Tsurutani, Yuya ;

Koshizaka, Masaya ;

Mezawa, Morito ;

Ishikawa, Takahiro ;

Takemoto, Minoru ;

Yokote, Koutaro .

GERIATRICS & GERONTOLOGY INTERNATIONAL, 2010, 10 (04) :319-323

[10] Lung cancer associated with Werner's syndrome: a case report and review of the literature [J].

Yamanaka, A ;

Hirai, T ;

Ohtake, Y ;

Kitagawa, M .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 1997, 27 (06) :415-418

← 1 2 →