Von Willebrand factor and hematogenous cancer metastasis under flow

被引：2

作者：

Xu, Wenxuan ^{[1
,2
]}

Tan, Xi ^{[1
,2
]}

Li, Morgan L. ^{[1
,2
]}

Xu, Hanzhi ^{[1
,2
,3
]}

Villegas, Jasmine ^{[1
,2
,3
]}

Fu, Hongxia ^{[1
,2
,3
,4
]}

机构：

[1] Univ Washington, Dept Med, Div Hematol & Oncol, Seattle, WA 98195 USA

[2] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA

[3] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[4] Bloodworks Res Inst, Seattle, WA 98102 USA

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2024年 / 12卷

基金：

美国国家卫生研究院;

关键词：

Von Willebrand factor; cancer; metastasis; flow; platelets; endothelial cells; FACTOR SELF-ASSOCIATION; HUMAN ENDOTHELIAL-CELLS; FACTOR-VIII; P-SELECTIN; INTEGRIN ALPHA(V)BETA(3); ACTIVATED PLATELETS; FACTOR MULTIMERS; FACTOR STRINGS; FACTOR FIBERS; TUMOR-GROWTH;

D O I：

10.3389/fcell.2024.1435718

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hematogenous metastasis involves cancer cell migration to different locations from the primary tumor through the blood circulation. Von Willebrand factor (VWF) has been shown to play an important role in tumor cell adhesion to and extravasation from the endothelial cell lining of blood vessel walls during cancer metastasis. VWF may contribute to this process by interacting with tumor cells, endothelial cells, and platelets through various cell membrane receptors, such as platelet glycoprotein (GP)Ib alpha, P-selectin, alpha nu beta 3 and alpha IIb beta 3 integrins, and glycocalyx. Blood flow can mechanically extend and activate VWF to bind platelets and associate intermolecularly with other VWF molecules in plasma or on the surface of endothelial cells, cancer cells, or platelets. This suggests a mechanoregulatory role of VWF in mediating the interactions between VWF and these cells to promote cancer cell adhesion to blood vessels. In this review, we will summarize the current knowledge of VWF function and the role of hydrodynamic forces in hematogenous cancer metastasis.

引用

页数：9

共 106 条

[1] Platelets adhere to and translocate on von Willebrand factor presented by endothelium in simulated veins [J].