Natural plant-derived polysaccharides targeting macrophage polarization: a promising strategy for cancer immunotherapy

被引:3
作者
Wei, Jingyang [1 ]
Dai, Yanpeng [2 ]
Zhang, Ni [3 ]
Wang, Zijian [4 ]
Tian, Xinchen [5 ]
Yan, Tinghao [3 ]
Jin, Xiaohan [6 ,7 ]
Jiang, Shulong [1 ,7 ]
机构
[1] Shandong Univ Tradit Chinese Med, Coll Clin Med 2, Jinan, Peoples R China
[2] Shandong Acad Chinese Med, Inst Chinese Med Proc, Jinan, Peoples R China
[3] Shandong Univ, Cheeloo Coll Med, Jinan, Shandong, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China
[5] Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Shandong, Peoples R China
[6] Shandong Univ Tradit Chinese Med, Ctr Postdoctoral Studies, Jinan, Peoples R China
[7] Jining First Peoples Hosp, Clin Med Lab Ctr, Jining, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金
中国国家自然科学基金;
关键词
polysaccharide; tumor microenvironment; macrophage; polarization; anticancer immunotherapy; TUMOR-ASSOCIATED MACROPHAGES; NF-KAPPA-B; WATER-SOLUBLE POLYSACCHARIDES; ACTIVATES T-LYMPHOCYTES; IMMUNOMODULATORY ACTIVITY; STRUCTURAL-CHARACTERIZATION; ASTRAGALUS POLYSACCHARIDE; NONALCOHOLIC STEATOHEPATITIS; IMMUNOLOGICAL ACTIVITY; GALECTIN-3; INHIBITOR;
D O I
10.3389/fimmu.2024.1408377
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tumor associated macrophages (TAMs) are the predominant innate immune cells in the tumor microenvironment (TME). Cytokines induce the differentiation of macrophages into distinct types of TAMs, primarily characterized by two phenotypes: M1-polarized and M2-polarized. Cancer growth is suppressed by M1-polarized macrophages and promoted by M2-polarized macrophages. The regulation of macrophage M1 polarization has emerged as a promising strategy for cancer immunotherapy. Polysaccharides are important bioactive substances found in numerous plants, manifesting a wide range of noteworthy biological actions, such as immunomodulation, anti-tumor effects, antioxidant capabilities, and antiviral functions. In recent years, there has been a significant increase in interest regarding the immunomodulatory and anti-tumor properties of polysaccharides derived from plants. The regulatory impact of polysaccharides on the immune system is mainly associated with the natural immune response, especially with the regulation of macrophages. This review provides a thorough analysis of the regulatory effects and mechanisms of plant polysaccharides on TAMs. Additionally, an analysis of potential opportunities for clinical translation of plant polysaccharides as immune adjuvants is presented. These insights have greatly advanced the research of plant polysaccharides for immunotherapy in tumor-related applications.
引用
收藏
页数:16
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