Immune-Related Toxicity in NSCLC: Current State- of-the-Art and Emerging Clinical Challenges

被引：8

作者：

O'Leary, Caroline L. ^{[1
,2
]}

Pierce, Nicole ^{[1
,2
]}

Patel, Sandip P. ^{[3
]}

Naidoo, Jarushka ^{[1
,2
,4
]}

机构：

[1] Beaumont Hosp, Beaumont RCSI Canc Ctr, Dept Oncol, Dublin, Ireland

[2] RCSI Univ Hlth Sci, Dublin, Ireland

[3] Univ Calif San Diego, Dept Med, San Diego, CA USA

[4] Johns Hopkins Univ, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

来源：

JOURNAL OF THORACIC ONCOLOGY | 2024年 / 19卷 / 03期

关键词：

Immunotherapy; Immune checkpoint inhibitor; Immune-related adverse events; Lung cancer; CHECKPOINT INHIBITORS; NIVOLUMAB; PEMBROLIZUMAB; IMMUNOTHERAPY; CHEMOTHERAPY; PNEUMONITIS; DOCETAXEL; BLOCKADE; THERAPY;

D O I：

10.1016/j.jtho.2023.11.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors have become standard-of- care for the treatment of NSCLC; however, their use brings with it the risk of a unique set of inflammatory side effects, termed immune-related adverse events (irAEs). The recognition, diagnosis, and management of irAEs have become essential to clinical practice, with the potential for high-grade toxicities affecting treatment decision-making. This manuscript provides a state-of-the-art review of irAEs as they pertain to patients with NSCLC, by summarizing the common and severe toxicities of the standard immune checkpoint inhibitor regimens and clinical treatment settings relevant to this disease and future directions. (c) 2023 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).

引用

页码：395 / 408

页数：14

共 86 条

[11] Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial [J].

Cascone, Tina ;

Leung, Cheuk H. ;

Weissferdt, Annikka ;

Pataer, Apar ;

Carter, Brett W. ;

Godoy, Myrna C. B. ;

Feldman, Hope ;

William Jr, William N. ;

Xi, Yuanxin ;

Basu, Sreyashi ;

Sun, Jing Jing ;

Yadav, Shalini S. ;

Rojas Alvarez, Frank R. ;

Lee, Younghee ;

Mishra, Aditya K. ;

Chen, Lili ;

Pradhan, Monika ;

Guo, Haiping ;

Sinjab, Ansam ;

Zhou, Nicolas ;

Negrao, Marcelo V. ;

Le, Xiuning ;

Gay, Carl M. ;

Tsao, Anne S. ;

Byers, Lauren Averett ;

Altan, Mehmet ;

Glisson, Bonnie S. ;

Fossella, Frank V. ;

Elamin, Yasir Y. ;

Blumenschein, George ;

Zhang, Jianjun ;

Skoulidis, Ferdinandos ;

Wu, Jia ;

Mehran, Reza J. ;

Rice, David C. ;

Walsh, Garrett L. ;

Hofstetter, Wayne L. ;

Rajaram, Ravi ;

Antonoff, Mara B. ;

Fujimoto, Junya ;

Solis, Luisa M. ;

Parra, Edwin R. ;

Haymaker, Cara ;

Wistuba, Ignacio I. ;

Swisher, Stephen G. ;

Vaporciyan, Ara A. ;

Lin, Heather Y. ;

Wang, Jing ;

Gibbons, Don L. ;

Jack Lee, J. .

NATURE MEDICINE, 2023, 29 (3) :593-604

[12] A Novel Radiogenomics Biomarker for Predicting Treatment Response and Pneumotoxicity From Programmed Cell Death Protein or Ligand-1 Inhibition Immunotherapy in NSCLC [J].

Chen, Mitchell ;

Lu, Haonan ;

Copley, Susan J. ;

Han, Yidong ;

Logan, Andrew ;

Viola, Patrizia ;

Cortellini, Alessio ;

Pinato, David J. ;

Power, Danielle ;

Aboagye, Eric O. .

JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (06) :718-730

[13] Radiation Versus Immune Checkpoint Inhibitor Associated Pneumonitis: Distinct Radiologic Morphologies [J].

Chen, Xuguang ;

Sheikh, Khadija ;

Nakajima, Erica ;

Lin, Cheng Ting ;

Lee, Junghoon ;

Hu, Chen ;

Hales, Russell K. ;

Forde, Patrick M. ;

Naidoo, Jarushka ;

Khinh Ranh Voong .

ONCOLOGIST, 2021, 26 (10) :E1822-E1832

[14] Thyroid-related adverse events induced by immune checkpoint inhibitors [J].

Chera, Alexandra ;

Stancu, Andreea Lucia ;

Bucur, Octavian .

FRONTIERS IN ENDOCRINOLOGY, 2022, 13

[15] Resolution of Severe Ipilimumab-Induced Hepatitis After Antithymocyte Globulin Therapy [J].

Chmiel, Katarzyna D. ;

Suan, Dan ;

Liddle, Christopher ;

Nankivell, Brian ;

Ibrahim, Ramy ;

Bautista, Charmaine ;

Thompson, John ;

Fulcher, David ;

Kefford, Richard .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (09) :E237-E240

[16] Severe Sotorasib-Related Hepatotoxicity and Non-Liver Adverse Events Associated With Sequential Anti-Programmed Cell Death (Ligand)1 and Sotorasib Therapy in KRASG12C-Mutant Lung Cancer [J].

Chour, Ali ;

Denis, Julie ;

Mascaux, Celine ;

Zysman, Maeva ;

Bigay-Game, Laurence ;

Swalduz, Aurelie ;

Gounant, Valerie ;

Cortot, Alexis ;

Darrason, Marie ;

Fallet, Vincent ;

Auclin, Edouard ;

Basse, Clemence ;

Tissot, Claire ;

Decroisette, Chantal ;

Bombaron, Pierre ;

Giroux-Leprieur, Etienne ;

Odier, Luc ;

Brosseau, Solenn ;

Creusot, Quentin ;

Guecamburu, Marina ;

Meersseman, Corentin ;

Rochand, Adrien ;

Costantini, Adrien ;

Gaillard, Claire Marine ;

Wasielewski, Eric ;

Girard, Nicolas ;

Cadranel, Jacques ;

Lafitte, Claire ;

Lebosse, Fanny ;

Duruisseaux, Michael .

JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (10) :1408-1415

[17] Systematic comparison with autoimmune liver disease identifies specific histological features of immune checkpoint inhibitor-related adverse events [J].

Coukos, Alexander ;

Vionnet, Julien ;

Obeid, Michel ;

Bouchaab, Hasna ;

Peters, Solange ;

Latifyan, Sofiya ;

Wicky, Alexandre ;

Michielin, Olivier ;

Chtioui, Haithem ;

Moradpour, Darius ;

Fasquelle, Francois ;

Sempoux, Christine ;

Fraga, Montserrat .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (10)

[18] Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis [J].

Dubin, Krista ;

Callahan, Margaret K. ;

Ren, Boyu ;

Khanin, Raya ;

Viale, Agnes ;

Ling, Lilan ;

No, Daniel ;

Gobourne, Asia ;

Littmann, Eric ;

Huttenhower, Curtis ;

Pamer, Eric G. ;

Wolchok, Jedd D. .

NATURE COMMUNICATIONS, 2016, 7

[19] High-Grade Pneumonitis Events in Patients With Unresectable, Locally Advanced NSCLC Treated With Definitive Chemoradiation Followed by Adjuvant Durvalumab [J].

Ellison, Ciani ;

Martens, Michael ;

Argote, Juliana Alvarez ;

Benz, Samantha ;

Currey, Adam ;

Johnstone, Candice ;

Klawikowski, Slade ;

Livingston, Katie ;

Longo, John M. ;

Menon, Smitha ;

Choudens, Saryleine Ortiz de ;

Puckett, Lindsay ;

Retseck, Janet ;

Shukla, Monica ;

Thompson, Jonathan ;

Gore, Elizabeth .

JTO CLINICAL AND RESEARCH REPORTS, 2024, 5 (12)

[20] Paraneoplastic Disorders in Thymoma Patients [J].

Evoli, Amelia ;

Lancaster, Eric .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (09) :S143-S147

← 1 2 3 4 5 6 7 8 9 →