Blueberries in focus: Exploring the phytochemical potentials and therapeutic applications

被引:23
作者
Ashique, Sumel [1 ,2 ]
Mukherjee, Tuhin [3 ]
Mohanty, Satyajit [3 ]
Garg, Ashish [4 ]
Mishra, Neeraj [5 ]
Kaushik, Monika [5 ]
Bhowmick, Mithun [1 ]
Chattaraj, Bornika [6 ]
Mohanto, Sourav [7 ]
Srivastava, Shriyansh [8 ,9 ]
Taghizadeh-Hesary, Farzad [10 ,11 ]
机构
[1] Bengal Coll Pharmaceut Sci & Res, Dept Pharmaceut, Durgapur 713212, W Bengal, India
[2] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
[3] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Div Pharmacol, Ranchi 835215, Jharkhand, India
[4] Guru Ramdas Khalsa Inst Sci & Technol, Pharm, Jabalpur 483001, MP, India
[5] Amity Univ Gwalior, Amity Inst Pharm, Gwalior 474005, Madhya Pradesh, India
[6] Sanaka Educ Trusts Grp Inst, Dept Pharm, Malandighi 713212, W Bengal, India
[7] Yenepoya Univ, Yenepoya Pharm Coll & Res Ctr, Dept Pharmaceut, Mangalore 575018, Karnataka, India
[8] Galgotias Univ, Sch Med & Allied Sci, Dept Pharm, Greater Noida 203201, India
[9] Delhi Pharmaceut Sci & Res Univ DPSRU, Dept Pharmacol, Sect Pushp Vihar 3, New Delhi 110017, India
[10] Iran Univ Med Sci, Senses Hlth Inst 5, ENT & Head & Neck Res Dept, Sch Med, Tehran, Iran
[11] Iran Univ Med Sci, Senses Hlth Inst 5, ENT & Head & Neck Res Ctr, Sch Med, Tehran, Iran
关键词
Blueberry; Phytochemicals; Gut microbiota; Anthocyanins; Bioactive substances; VACCINIUM-CORYMBOSUM L; RADICAL ABSORBING CAPACITY; INDUCED OXIDATIVE STRESS; ANTIOXIDANT CAPACITY; INSULIN-RESISTANCE; PHENOLIC-ACIDS; BLOOD-PRESSURE; INDUCED DAMAGE; FERULIC ACID; KAPPA-B;
D O I
10.1016/j.jafr.2024.101300
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Blueberries, which belong to the Vaccinium spp. Genus, have attracted considerable interest because of their abundant phytochemical composition and potential for medicinal uses. The present study examines the many phytochemicals found in blueberries, such as anthocyanins, flavonoids, phenolic acids, and stilbenes, as well as their biological activities contributing to the health benefits of blueberries. Anthocyanins, the primary pigments that give blueberries their unique color, are renowned for their powerful antioxidant capabilities. These substances counteract oxidative stress by neutralizing free radicals, decreasing the likelihood of developing chronic illnesses such as cardiovascular disease, cancer, and neurological disorders. Furthermore, the presence of flavonoids and phenolic acids in blueberries contributes to their ability to reduce inflammation, prevent cancer, and protect the brain, improving their potential for therapeutic use. This study delves into the bioavailability and metabolism of these phytochemicals, specifically examining the impact of factors like food composition, gut microorganisms, and individual metabolic variations on their effectiveness. Both clinical and preclinical studies provide strong evidence for the beneficial effects of blueberries on multiple health factors, such as enhanced cognitive function, lowered blood pressure, and improved insulin sensitivity. These findings suggest that blueberries may play a significant role in managing conditions like Alzheimer's disease, hypertension, and diabetes. Moreover, this study examines the synergistic impacts of blueberry phytochemicals, suggesting that the health advantages of blueberries arise not alone from individual substances but also from their collective interactions. Proposed future study areas include the advancement of functional foods and nutraceuticals derived from blueberries, as well as the need for standardized clinical studies to determine appropriate dose guidelines and ensure long-term safety. Overall, the significant variety of phytochemicals in blueberries and their potential for therapeutic use make them a promising functional food. Further research into these substances' mechanisms of action and therapeutic uses will clarify their function in enhancing human health and avoiding illness.
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页数:37
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