Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome

被引：0
作者：
Lloyd, K. C. Kent [1 ,2 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Surg, Davis, CA 95616 USA
[2] Univ Calif Davis, Mouse Biol Program, Davis, CA 95616 USA
来源：
MAMMALIAN GENOME | 2024年 / 35卷 / 04期
基金：
美国国家卫生研究院;
关键词：
WIDE; IDENTIFICATION; DISCOVERY; RESOURCE;
D O I：
10.1007/s00335-024-10068-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The International Mouse Phenotyping Consortium (IMPC) is a worldwide effort producing and phenotyping knockout mouse lines to expose the pathophysiological roles of all genes in human diseases and make mice and data available and accessible to the global research community. It has created new knowledge on the function of thousands of genes for which little to anything was known. This new knowledge has informed the genetic basis of rare diseases, posited gene product influences on common diseases, influenced research on targeted therapies, revealed functional pleiotropy, essentiality, and sexual dimorphism, and many more insights into the role of genes in health and disease. Its scientific contributions have been many and widespread, however there remain thousands of "dark" genes yet to be illuminated. Nearing the end of its current funding cycle, IMPC is at a crossroads. The vision forward is clear, the path to proceed less so.
引用
收藏
页码：537 / 543
页数：7
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