Cariprazine and clozapine combination for the treatment of psychosis in a young, female patient with schizophrenia: a case report

被引：2

作者：

Dmuhovskis, Anzejs ^{[1
,2
]}

Taube, Maris ^{[1
,2
,3
]}

机构：

[1] Riga Stradins Univ, Fac Residency, Riga, Latvia

[2] Riga Ctr Psychiat & Narcol, Dept Depress & Crisis, Riga, Latvia

[3] Riga Stradins Univ, Dept Psychosomat Med & Psychotherapy, Riga, Latvia

来源：

FRONTIERS IN PSYCHIATRY | 2024年 / 15卷

关键词：

cariprazine; clozapine; psychosis; polypharmacy; treatment; young female;

D O I：

10.3389/fpsyt.2024.1452980

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The task of a psychiatrist is to select the most appropriate medication or combination of drugs to treat the symptoms of schizophrenia while minimizing the risk of side effects and ensuring the patient achieves the highest level of functioning possible. This is a challenging task as the action of each drug or group of drugs is different. The efficacy of cariprazine, which affects D3 receptors as a D3/D2 receptor partial agonist, has been extensively studied and is one of the first medication choices by practicing psychiatrists when treating patients with negative symptomatology. In this clinical case, we demonstrate the effective and safe treatment of a patient's positive and affective symptoms using a combination of cariprazine, clozapine, and venlafaxine.

引用

页数：5

共 20 条

[1] Prolactin elevation with quetiapine [J].

Alexiadis, M ;

Whitehorn, D ;

Woodley, H ;

Kopala, L .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (09) :1608-1609

[2]

[Anonymous], 2010, ICD-10 Version:2010

[3] Remission of Persistent Negative Symptoms and Psychosocial Consequences by Combined Clozapine and Cariprazine Treatment in a Patient With Long-Standing Treatment-Resistant Schizoaffective Disorder [J].

Bogren, Mats ;

Soltesz, Monica ;

Hjorth, Stephan .

FRONTIERS IN PSYCHIATRY, 2022, 13

[4]

Boland RJ., 2022, Kaplan Sadocks synopsis of psychiatry: behavioral sciences/clinical psychiatry, V12th ed, P1181

[5] Antipsychotic medication for women with schizophrenia spectrum disorders [J].

Brand, Bodyl A. ;

Haveman, Yudith R. A. ;

de Beer, Franciska ;

de Boer, Janna N. ;

Dazzan, Paola ;

Sommer, Iris E. C. .

PSYCHOLOGICAL MEDICINE, 2022, 52 (04) :649-663

[6] Cariprazine for acute and maintenance treatment of adults with schizophrenia: an evidence-based review and place in therapy [J].

Citrome, Leslie .

NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2018, 14 :2563-2577

[7] Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors [J].

Correll, Christoph U. ;

Solmi, Marco ;

Croatto, Giovanni ;

Schneider, Lynne Kolton ;

Rohani-Montez, S. Christy ;

Fairley, Leanne ;

Smith, Nathalie ;

Bitter, Istvan ;

Gorwood, Philip ;

Taipale, Heidi ;

Tiihonen, Jari .

WORLD PSYCHIATRY, 2022, 21 (02) :248-271

[8] Treating schizophrenia with cariprazine: from clinical research to clinical practice. Real world experiences and recommendations from an International Panel [J].

Fagiolini, Andrea ;

Alcala, Jose Angel ;

Aubel, Thomas ;

Bienkiewicz, Wojciech ;

Bogren, Mats Magnus Knut ;

Gago, Joaquim ;

Cerveri, Giancarlo ;

Colla, Michael ;

Sanchez, Francisco Collazos ;

Cuomo, Alessandro ;

Helge, Frieling ;

Iacoponi, Eduardo ;

Karlsson, Per-Axel ;

Peddu, Pradeep ;

Pettorruso, Mauro ;

Pereira, Henrique Jorge Ramos ;

Scholin, Johan Sahlsten ;

Vernaleken, Ingo Bernd .

ANNALS OF GENERAL PSYCHIATRY, 2020, 19 (01)

[9] Schizophrenia [J].

Hasan, Alkomiet ;

Falkai, Peter ;

Lehmann, Isabell ;

Gaebel, Wolfgang .

DEUTSCHES ARZTEBLATT INTERNATIONAL, 2020, 117 (24) :412-+

[10] The More, the Merrier horizontal ellipsis ? Antipsychotic Polypharmacy Treatment Strategies in Schizophrenia From a Pharmacology Perspective [J].

Hjorth, Stephan .

FRONTIERS IN PSYCHIATRY, 2021, 12

← 1 2 →