Organizational challenges for partial heart transplantation

被引：0

作者：

Alexander, Vincent S. ^{[1
,2
]}

Vogel, Andrew D. ^{[1
,2
]}

Silvano, Zachary T. ^{[1
,2
]}

Javed, Herra ^{[1
]}

Mitta, Alekhya ^{[1
,3
]}

Rajab, Taufiek Konrad ^{[1
]}

机构：

[1] Arkansas Childrens Hosp, Dept Cardiovasc Surg, 1 Childrens Way, Little Rock, AR 72202 USA

[2] Alabama Coll Osteopath Med, Div Res, 445 Hlth Sci Blvd, Dothan, AL 36303 USA

[3] Univ South Carolina, Div Res, 1705 Coll St,Close-Hipp Suite 552, Columbia, SC 29208 USA

来源：

FUTURE CARDIOLOGY | 2024年 / 20卷 / 13期

基金：

美国国家卫生研究院;

关键词：

cryopreservation; donor heart allocation; ethical considerations; immunosuppression; partial heart transplantation; pediatric cardiac transplantation; AORTIC-VALVE-REPLACEMENT; FUTURE;

D O I：

10.1080/14796678.2024.2404775

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Partial heart transplantation (PHT) has emerged as a new treatment strategy to correct unrepairable heart valve dysfunction in pediatric patients. PHT selectively replaces the dysfunctional components of the recipient's heart and spares the native ventricles. As a result, the transplant biology of PHTs differs from heart transplants. Notably, donor hearts that are unsuitable for whole heart transplantation can be used, graft preservation can be prolonged and immunosuppression levels can be lowered. These nuances of PHT transplant biology have important implications for organizational aspects of PHT clinical application.

引用

页码：719 / 728

页数：10

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