Autoantibody production is a hallmark of systemic sclerosis (SSc) and the most extensively studied role of B cells in the pathogenesis of the disease. However, the potential involvement of innate immune molecules in B-cell dysfunction in SSc is less understood. B-cell activation is an early event in the pathogenesis of SSc and is influenced by complement receptors (CRs) and Toll-like receptors (TLRs), shaping antibody responses. CR2 and CR1 modulate B-cell activation, and the roles of CR3 and CR4 are associated with autoimmune conditions. We investigated the expression of CRs in B cells from patients with the more severe form of the disease, diffuse cutaneous SSc (dcSSc), and the effect of TLR CD180 ligation on their expression. We found no significant difference in the basal expression of CD21 and CD11c in B cells between dcSSc and healthy controls (HCs). However, reduced basal CD11b expression in B cells in dcSSc compared to HCs, accompanied by a decrease in CD35 and an increase in CD11c expression following CD180 ligation may promote plasma cell formation and autoantibody production. Additionally, we searched for correlations between dcSSc-associated anti-DNA topoisomerase I (Scl-70) autoantibody, anti-citrate synthase (CS) natural autoantibody and complement component 3 (C3) levels and found a negative correlation between C3 and anti-CS autoantibody in dcSSc but not in HCs, supporting the hypothesis that natural autoantibodies could activate the complement system contributing to tissue injury in SSc.
机构:
Hosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Fonte, Eleonora
Vilia, Maria Giovanna
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Hosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Vilia, Maria Giovanna
Reverberi, Daniele
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机构:
IRCCS AOU S Martino IST, UOC Patol Mol, Genoa, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Reverberi, Daniele
Sana, Ilenia
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机构:
Hosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Sana, Ilenia
Scarfo, Lydia
论文数: 0引用数: 0
h-index: 0
机构:
Hosp San Raffaele, IRCCS, B Cell Neoplasia Unit, Div Expt Oncol, Milan, Italy
Hosp San Raffaele, IRCCS, Strateg Res Program CLL, Div Expt Oncol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Scarfo, Lydia
Ranghetti, Pamela
论文数: 0引用数: 0
h-index: 0
机构:
Hosp San Raffaele, IRCCS, B Cell Neoplasia Unit, Div Expt Oncol, Milan, Italy
Hosp San Raffaele, IRCCS, Strateg Res Program CLL, Div Expt Oncol, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Ranghetti, Pamela
Orfanelli, Ugo
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h-index: 0
机构:
Hosp San Raffaele, Div Genet & Cell Biol, Age Related Dis Unit, IRCCS, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Orfanelli, Ugo
Cenci, Simone
论文数: 0引用数: 0
h-index: 0
机构:
Hosp San Raffaele, Div Genet & Cell Biol, Age Related Dis Unit, IRCCS, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Cenci, Simone
Cutrona, Giovanna
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS AOU S Martino IST, UOC Patol Mol, Genoa, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Cutrona, Giovanna
Ghia, Paolo
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机构:
Hosp San Raffaele, IRCCS, B Cell Neoplasia Unit, Div Expt Oncol, Milan, Italy
Hosp San Raffaele, IRCCS, Strateg Res Program CLL, Div Expt Oncol, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
Ghia, Paolo
Muzio, Marta
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机构:
Hosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, ItalyHosp San Raffaele, Div Expt Oncol, Cell Signaling Unit, IRCCS, Milan, Italy
机构:
Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Hammond, Talia
Lee, Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Royal Perth Hosp, Dept Microbiol & Infect Dis, Perth, WA, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Lee, Silvia
Watson, Mark W.
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h-index: 0
机构:
Royal Perth Hosp, Ctr Clin Immunol & Biomed Stat, Perth, WA, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Watson, Mark W.
Flexman, James P.
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h-index: 0
机构:
Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Flexman, James P.
Cheng, Wendy
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h-index: 0
机构:
Royal Perth Hosp, Dept Gastroenterol & Hepatol, Perth, WA, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Cheng, Wendy
Fernandez, Sonia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Fernandez, Sonia
Price, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
Royal Perth Hosp, Clin Immunol & Immunogenet, Perth, WA, AustraliaUniv Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Wu, Jun
Yang, Xiao
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Yang, Xiao
Zhang, Yun-Fang
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Zhang, Yun-Fang
Zhou, Shu-Feng
论文数: 0引用数: 0
h-index: 0
机构:
RMIT Univ, Sch Hlth Sci, Melbourne, Vic, AustraliaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Zhou, Shu-Feng
Zhang, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Zhang, Rui
Dong, Xiu-Qing
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Dong, Xiu-Qing
Fan, Jin-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Fan, Jin-Jin
Liu, Mei
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
Liu, Mei
Yu, Xue-Qing
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
机构:
Juntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Muto, Masahiro
Manfroi, Benoit
论文数: 0引用数: 0
h-index: 0
机构:
Univ Joseph Fourier U823, INSERM, Albert Bonniot Inst, Analyt Immunol Chron Pathol, Grenoble, FranceJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Manfroi, Benoit
Suzuki, Hitoshi
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Suzuki, Hitoshi
Joh, Kensuke
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Med, Dept Pathol, Sendai, Miyagi, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Joh, Kensuke
Nagai, Masaaki
论文数: 0引用数: 0
h-index: 0
机构:
Narita Mem Hosp, Div Nephrol & Diabetol, Toyohashi, Aichi, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Nagai, Masaaki
Wakai, Sachiko
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Hlth & Med Treatment Corp, Okubo Hosp, Dept Internal Med, Tokyo, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Wakai, Sachiko
Righini, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Grenoble Univ Hosp, Dept Otolaryngol Head & Neck Surg, Grenoble, FranceJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Righini, Christian
Maiguma, Masayuki
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Maiguma, Masayuki
Izui, Shozo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Geneva, Dept Pathol & Immunol, Geneva, SwitzerlandJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Izui, Shozo
Tomino, Yasuhiko
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Tomino, Yasuhiko
Huard, Bertrand
论文数: 0引用数: 0
h-index: 0
机构:
Univ Joseph Fourier U823, INSERM, Albert Bonniot Inst, Analyt Immunol Chron Pathol, Grenoble, FranceJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Huard, Bertrand
Suzuki, Yusuke
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, JapanJuntendo Univ, Div Nephrol, Dept Internal Med, Tokyo, Japan
Suzuki, Yusuke
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,
2017,
28
(04):
: 1227
-
1238
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Zhang, Ye
Lian, Jian-Qi
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Lian, Jian-Qi
Huang, Chang-Xing
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Huang, Chang-Xing
Wang, Jiu-Ping
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Wang, Jiu-Ping
Wei, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Wei, Xin
Nan, Xue-Ping
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Nan, Xue-Ping
Yu, Hai-Tao
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Yu, Hai-Tao
Jiang, Li-Li
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Jiang, Li-Li
Wang, Xiao-Qin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Wang, Xiao-Qin
Zhuang, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Zhuang, Yan
Li, Xin-Hong
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Li, Xin-Hong
Li, Yu
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Li, Yu
Wang, Ping-Zhong
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Wang, Ping-Zhong
Robek, Michael D.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USAFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China
Robek, Michael D.
Bai, Xue-Fan
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Ctr Infect Dis, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China