Hederagenin from Hedera helix Promotes Fat Browning in 3T3-L1 Adipocytes

被引:5
作者
Choi, Seung Min [1 ]
Lee, Ho Seon [1 ]
Lim, Sung Ho [1 ]
Choi, Gayoung [1 ]
Choi, Chang-Ik [1 ]
机构
[1] Dongguk Univ Seoul, Integrated Res Inst Drug Dev, Coll Pharm, Seoul 10326, South Korea
来源
PLANTS-BASEL | 2024年 / 13卷 / 19期
关键词
hederagenin; fat browning; Hedera helix; uncoupling protein 1; BEIGE ADIPOSE-TISSUE; OBESITY; FLAVONOIDS; SAPONINS; EXTRACT; PRDM16; FRUITS;
D O I
10.3390/plants13192789
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The prevalence of obesity is increasing globally, with approximately 700 million obese people worldwide. Currently, regulating energy homeostasis by increasing energy expenditure is attracting attention as a strategy for treating obesity. White adipose tissue is known to play a role in accumulating energy by storing excess energy, while brown adipose tissue expends energy and maintains body temperature. Thus, the browning of white adipose tissue has been shown to be effective in controlling obesity. Hedera helix (H. helix) has been widely used as a traditional medicine for various diseases. In several previous studies, hederagenin (HDG) from H. helix has demonstrated many biological activities. In this study, we investigated the antiobesity effect of HDG on fat browning in 3T3-L1 adipocytes. Consequent to HDG treatment, a reduction in lipid accumulation was measured through oil red O staining. In addition, this study investigated that HDG increases energy expenditure by upregulating the expression of several targets related to thermogenesis, including uncoupling protein 1 (UCP1). This process involves inhibiting lipogenesis via the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway and promoting lipolysis through the protein kinase A (PKA) pathway. HDG is expected to be effective in promoting fat browning, indicating its potential as a natural antiobesity candidate.
引用
收藏
页数:13
相关论文
共 49 条
[1]   BROWN ADIPOSE TISSUE AND HEAT PRODUCTION IN NEWBORN INFANT [J].
AHERNE, W ;
HULL, D .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1966, 91 (01) :223-&
[2]   Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline [J].
Apovian, Caroline M ;
Aronne, Louis J. ;
Bessesen, Daniel H. ;
McDonnell, Marie E. ;
Murad, M. Hassan ;
Pagotto, Uberto ;
Ryan, Donna H. ;
Still, Christopher D. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (02) :342-362
[3]   Obesity and Cancer Risk: Recent Review and Evidence [J].
Basen-Engquist, Karen ;
Chang, Maria .
CURRENT ONCOLOGY REPORTS, 2011, 13 (01) :71-76
[4]   Triterpene saponins from the fruits of Hedera helix [J].
Bedir, E ;
Kirmizibekmez, H ;
Sticher, O ;
Çalis, I .
PHYTOCHEMISTRY, 2000, 53 (08) :905-909
[5]   Non-adrenergic control of lipolysis and thermogenesis in adipose tissues [J].
Braun, Katharina ;
Oeckl, Josef ;
Westermeier, Julia ;
Li, Yongguo ;
Klingenspor, Martin .
JOURNAL OF EXPERIMENTAL BIOLOGY, 2018, 221
[6]   α-Hederin Potentiates 5-FU Antitumor Activity in Human Colon Adenocarcinoma Cells [J].
Bun, Sok-Siya ;
Elias, Riad ;
Baghdikian, Beatrice ;
Ciccolini, Joseph ;
Ollivier, Evelyne ;
Balansard, Guy .
PHYTOTHERAPY RESEARCH, 2008, 22 (10) :1299-1302
[7]   Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway [J].
Cheng, Long ;
Shi, Lu ;
He, Changhao ;
Wang, Chen ;
Lv, Yinglan ;
Li, Huimin ;
An, Yongcheng ;
Duan, Yuhui ;
Dai, Hongyu ;
Zhang, Huilin ;
Huang, Yan ;
Fu, Wanxin ;
Sun, Weiguang ;
Zhao, Baosheng .
CHINESE JOURNAL OF NATURAL MEDICINES, 2023, 21 (11) :812-829
[8]   Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus [J].
Cheng, Long ;
Wang, Jingkang ;
Dai, Hongyu ;
Duan, Yuhui ;
An, Yongcheng ;
Shi, Lu ;
Lv, Yinglan ;
Li, Huimin ;
Wang, Chen ;
Ma, Quantao ;
Li, Yaqi ;
Li, Pengfei ;
Du, Haifeng ;
Zhao, Baosheng .
ADIPOCYTE, 2021, 10 (01) :48-65
[9]   New Advances in Adaptive Thermogenesis: UCP1 and Beyond [J].
Chouchani, Edward T. ;
Kazak, Lawrence ;
Spiegelman, Bruce M. .
CELL METABOLISM, 2019, 29 (01) :27-37
[10]   POLYACETYLENES FROM THE FRUITS OF HEDERA-HELIX [J].
CHRISTENSEN, LP ;
LAM, J ;
THOMASEN, T .
PHYTOCHEMISTRY, 1991, 30 (12) :4151-4152