Nickel-catalysed reductive C-N bond cross-coupling between aryl halides and N-chloroamides

被引:1
|
作者
Luo, Yiting [1 ]
Yao, Jiacan [1 ]
He, Yunzhi [1 ]
Xu, Chang [1 ]
Liu, Dandan [1 ]
机构
[1] Kunming Med Univ, Sch Pharmaceut Sci, 1168 Western Chunrong Rd,Yuhua St, Kunming City 650500, Yunnan, Peoples R China
基金
中国国家自然科学基金;
关键词
BORONIC ACIDS; AMIDES; ARYLATION; MECHANISMS; EFFICIENT; DFT;
D O I
10.1039/d4ob00970c
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A method for the direct synthesis of N-aryl lactams and amides with aryl halides and N-chloroamides through a Ni-catalyzed reductive C-N coupling reaction has been developed. The reaction features the advantages of mild conditions, good functional group tolerance and broad substrate scope including drug-derived substrates, and also provided direct access to the key synthetic intermediates for some bioactive molecules, suggesting the practicability of this method. Finally, DFT calculations were performed to shed further light on the reaction mechanism and it was found that an amidyl radical might be involved.
引用
收藏
页码:6955 / 6959
页数:5
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