Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action

被引：6

作者：

Talib, Wamidh H. ^{[1
,2
]}

Baban, Media Mohammad ^{[3
]}

Bulbul, Mais Fuad ^{[3
]}

Al-Zaidaneen, Esraa ^{[3
]}

Allan, Aya ^{[3
]}

Al-Rousan, Eiman Wasef ^{[3
]}

Ahmad, Rahaf Hamed Yousef ^{[3
]}

Alshaeri, Heba K. ^{[4
]}

Alasmari, Moudi M. ^{[5
,6
]}

Law, Douglas ^{[2
]}

机构：

[1] Appl Sci Private Univ, Fac Allied Med Sci, Amman 11931, Jordan

[2] Inti Int Univ, Fac Hlth & Life Sci, Nilai 71800, Negeri Sembilan, Malaysia

[3] Appl Sci Private Univ, Dept Clin Pharm & Therapeut, Amman 11931, Jordan

[4] King Abdulaziz Univ, Fac Med, Dept Pharmacol, Rabigh 25724, Saudi Arabia

[5] King Saud bin Abdulaziz Univ Hlth Sci KSAU HS, Coll Med, Jeddah 21423, Saudi Arabia

[6] King Abdullah Int Med Res Ctr KAIMRC, Jeddah 22233, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

关键词：

natural products; Warburg effect; anticancer; angiogenesis; metastasis; human health; FATTY-ACID SYNTHASE; CELL LUNG-CANCER; RESVERATROL-INDUCED APOPTOSIS; HYPOXIA-INDUCIBLE FACTOR-1; PENTOSE-PHOSPHATE PATHWAY; EMODIN INDUCES APOPTOSIS; GROWTH IN-VITRO; DOWN-REGULATION; HEPATOCELLULAR-CARCINOMA; COLON-CANCER;

D O I：

10.3390/ijms25179593

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous biological functions, including metabolism. Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research. In this review, we delve into recent research examining the influence of natural products on altered cancer metabolism. Natural products were selected based on their ability to target cancer's altered metabolism. We identified the targets and explored the mechanisms of action of these natural products in influencing cellular energetics. Studies discussed in this review provide a solid ground for researchers to consider natural products in cancer treatment alone and in combination with conventional anticancer therapies.

引用

页数：46

共 261 条

[1] Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in CD-1 mice [J].

Afaq, F ;

Saleem, M ;

Krueger, CG ;

Reed, JD ;

Mukhtar, H .

INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (03) :423-433

[2] Triacylglycerol metabolism in adipose tissue [J].

Ahmadian, Mayam ;

Duncan, Robin E. ;

Jaworski, Kathy ;

Sarkadi-Nagy, Eszter ;

Sul, Hei Sook .

FUTURE LIPIDOLOGY, 2007, 2 (02) :229-237

[3] ENZYMATIC PATTERN OF PRENEOPLASTIC AND NEOPLASTIC LESIONS INDUCED IN THE KIDNEY OF CBA MICE BY 1,2-DIMETHYLHYDRAZINE [J].

AHN, YS ;

CHEMERIS, GY ;

TURUSOV, VS ;

BANNASCH, P .

TOXICOLOGIC PATHOLOGY, 1994, 22 (04) :415-422

[4] Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells [J].

Akkoc, Yunus ;

Berrak, Ozge ;

Arisan, Elif Damla ;

Obakan, Pinar ;

Coker-Gurkan, Ajda ;

Palavan-Unsal, Narcin .

BIOMEDICINE & PHARMACOTHERAPY, 2015, 71 :161-171

[5] Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells [J].

Amorim, Ricardo ;

Pinheiro, Celine ;

Miranda-Goncalves, Vera ;

Pereira, Helena ;

Moyer, Mary P. ;

Preto, Ana ;

Baltazar, Fatima .

CANCER LETTERS, 2015, 365 (01) :68-78

[6] Parthenolide and its Analogues: A New Potential Strategy for the Treatment of Triple-Negative Breast Tumors [J].

Araujo, Thaise Goncalves ;

Vecchi, Lara ;

Alves Pereira Lima, Paula Marynella ;

Ferreira, Everton Allan ;

Campos, Igor Moreira ;

Brandao, Douglas Cardoso ;

Guimaraes, Gabriela Silva ;

Ribeiro, Matheus Alves ;

da Silva Filho, Ademar Alves .

CURRENT MEDICINAL CHEMISTRY, 2020, 27 (39) :6628-6642

[7] In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2 [J].

Aslan, Erdem ;

Guler, Caglar ;

Adem, Sevki .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 (02) :314-317

[8] Natural products in drug discovery: advances and opportunities [J].

Atanasov, Atanas G. ;

Zotchev, Sergey B. ;

Dirsch, Verena M. ;

Supuran, Claudiu T. .

NATURE REVIEWS DRUG DISCOVERY, 2021, 20 (03) :200-216

[9] Antioxidant and anticancer properties of berries [J].

Baby, Bincy ;

Antony, Priya ;

Vijayan, Ranjit .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2018, 58 (15) :2491-2507

[10] Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development [J].

Baenke, Franziska ;

Peck, Barrie ;

Miess, Heike ;

Schulze, Almut .

DISEASE MODELS & MECHANISMS, 2013, 6 (06) :1353-1363

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