A Complex Condition; Polycystic Ovary Syndrome (PCOS): A Review of its Recent Advanced Treatment

被引:0
作者
Wal, Pranay [1 ]
Saxena, Bhagawati [2 ]
Aziz, Namra [1 ]
Pyne, Chandana [1 ]
Wal, Ankita [1 ]
Rathore, Shruti [3 ]
机构
[1] PSIT Pranveer Singh Inst Technol Pharm, Kanpur 209305, Uttar Pradesh, India
[2] Nirma Univ, Inst Pharm, Dept Pharmacol, SG Highway, Ahmadabad 382481, India
[3] LCIT Sch Pharm, Bilaspur 495220, Chhattisgarh, India
关键词
Polycystic ovaries; obesity; hormonal imbalance; infertility; hirusitism; menstrual cycle; N-ACETYL-CYSTEINE; LIFE-STYLE MODIFICATION; IN-VITRO FERTILIZATION; INSULIN-RESISTANCE; BARIATRIC SURGERY; CLOMIPHENE CITRATE; OBESE-PATIENTS; DOUBLE-BLIND; AROMATASE INHIBITORS; METFORMIN TREATMENT;
D O I
10.2174/0115734048259334231020120628
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women worldwide. It refers to a condition that often has 'poly' liquid containing sacks around ovaries. It affects reproductive-aged females, giving rise to menstrual and related reproductive issues. PCOS is marked by hormonal imbalance, often resulting in hyperandrogenism. Women with PCOS might experience abnormal insulin activity and complications such as acne, mood swings, hirsutism, obesity, and infertility. The disease is linked with severe clinical ailments such as type 2 diabetes (T2DM), cardiovascular diseases (CVDs), and cancer. A faulty lifestyle, neuroendocrine factors, genetic causes, and androgen exposures often cause PCOS. The approach of society towards physiological problems such as PCOS in women is that it must be under the veil that is the ultimate barrier to the early diagnosis of PCOS. Thus, this review summarizes the causes, symptoms, pathophysiology, diagnosis, and possible treatment (medical, herbal, and lifestyle improvement, acupuncture, and bariatric surgery) related to PCOS.
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页数:18
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共 168 条
[1]  
Abinaya S, 2019, Res J Life Sci Bioinform Pharmac Chem Sci, V1, P179, DOI DOI 10.26479/2019.0501.18
[2]   Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article [J].
Ajmal, Nida ;
Khan, Sanam Zeib ;
Shaikh, Rozeena .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2019, 3
[3]   The antiandrogenic effect of flutamide improves uterine perfusion in women with polycystic ovary syndrome [J].
Ajossa, S ;
Guerriero, S ;
Paoletti, AM ;
Orrù, M ;
Melis, GB .
FERTILITY AND STERILITY, 2002, 77 (06) :1136-1140
[4]   Recent Advances in the Management of Polycystic Ovary Syndrome: A Review Article [J].
Akre, Shivani ;
Sharma, Kapil ;
Chakole, Swarupa ;
Wanjari, Mayur B. .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (08)
[5]   Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences [J].
Anagnostis, Panagiotis ;
Tarlatzis, Basil C. ;
Kauffman, Robert P. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 86 :33-43
[6]   Metabolic and Hormonal Changes Induced by Pioglitazone in Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Clinical Trial [J].
Aroda, Vanita R. ;
Ciaraldi, Theodore P. ;
Burke, Paivi ;
Mudaliar, Sunder ;
Clopton, Paul ;
Phillips, Susan ;
Chang, R. Jeffrey ;
Henry, Robert R. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (02) :469-476
[7]   Ultrasound criteria in the diagnosis of polycystic ovary syndrome (PCOS) [J].
Atiomo, WU ;
Pearson, S ;
Shaw, S ;
Prentice, A ;
Dubbins, P .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2000, 26 (06) :977-980
[8]   Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebo-controlled trial [J].
Azziz, R ;
Ehrmann, D ;
Legro, RS ;
Whitcomb, RW ;
Hanley, R ;
Fereshetian, AG ;
O'Keefe, M ;
Ghazzi, MN .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (04) :1626-1632
[9]   Polycystic Ovary Syndrome [J].
Azziz, Ricardo .
OBSTETRICS AND GYNECOLOGY, 2018, 132 (02) :321-336
[10]   The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report [J].
Azziz, Ricardo ;
Carmina, Enrico ;
Dewailly, Didier ;
Diamanti-Kandarakis, Evanthia ;
Escobar-Morreale, Hector F. ;
Futterweit, Walter ;
Janssen, Onno E. ;
Legro, Richard S. ;
Norman, Robert J. ;
Taylor, Ann E. ;
Witchel, Selina F. .
FERTILITY AND STERILITY, 2009, 91 (02) :456-488