The emerging role of osteoclasts in the treatment of bone metastases: rationale and recent clinical evidence

被引：4
作者：
Liu, Youjun [1 ]
Chen, Huanshi [1 ]
Chen, Tong [1 ]
Qiu, Guowen [1 ]
Han, Yu [2 ]
机构：
[1] Liuzhou Municipal Liutie Cent Hosp, Dept Spinal Surg, Liuzhou, Peoples R China
[2] Zhengzhou Univ, Dept Orthoped, Affiliated Hosp 1, Zhengzhou, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
osteoclasts; bone metastasis; antiresorptive drugs; therapeutic targets; targeted therapy; BREAST-CANCER PATIENTS; ADJUVANT ZOLEDRONIC ACID; PLACEBO-CONTROLLED TRIAL; SKELETAL-RELATED EVENTS; ORAL SODIUM CLODRONATE; PHASE-III TRIAL; DOUBLE-BLIND; CATHEPSIN-K; SRC KINASE; OPEN-LABEL;
D O I：
10.3389/fonc.2024.1445025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The occurrence of bone metastasis is a grave medical concern that substantially impacts the quality of life in patients with cancer. The precise mechanisms underlying bone metastasis remain unclear despite extensive research efforts, and efficacious therapeutic interventions are currently lacking. The ability of osteoclasts to degrade the bone matrix makes them a crucial factor in the development of bone metastasis. Osteoclasts are implicated in several aspects of bone metastasis, encompassing the formation of premetastatic microenvironment, suppression of the immune system, and reactivation of quiescent tumor cells. Contemporary clinical interventions targeting osteoclasts have proven effective in mitigating bone-related symptoms in patients with cancer. This review comprehensively analyzes the mechanistic involvement of osteoclasts in bone metastasis, delineates potential therapeutic targets associated with osteoclasts, and explores clinical evidence regarding interventions targeting osteoclasts.
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页数：16
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