Microglia's heroic battle against neurodegeneration

被引：0

作者：

Kattimani, Yogita M. ^{[1
]}

Waisman, Ari ^{[1
,2
,3
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Res Ctr Immunotherapy, Mainz, Germany

[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Focus Program Neurobiol, Mainz, Germany

来源：

NEURON | 2024年 / 112卷 / 16期

关键词：

D O I：

10.1016/j.neuron.2024.07.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this issue of Neuron, , Chadarevian et al.1 1 and Munro et al.2 2 demonstrate how the absence of homeostatic microglia leads to severe neuropathologies, including axonal spheroids, calcifications, myelination abnormalities, and gliosis, associated with leukoencephalopathy and age-related neurodegeneration. Transplantation of healthy microglia can reverse these conditions, opening new avenues for therapeutic research.

引用

页码：2661 / 2663

页数：3

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