'Living drugs' target CD70 in advanced renal tumors

被引:0
|
作者
Wagner, Kilian [1 ]
Siska, Peter J. [1 ]
机构
[1] Univ Hosp Regensburg, Dept Internal Med Hematol & Med Oncol 3, Regensburg, Germany
关键词
D O I
10.1016/j.tips.2024.07.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cellular therapies against solid tumors face three major barriers: low persistence, insufficient specificity, and high costs. In a recent study, Pal et al. tackle these challenges in kidney cancer by using novel, 'persistence-tuned' allogeneic chimeric antigen receptor (CAR) T cells directed against a stable antigen.
引用
收藏
页码:757 / 759
页数:3
相关论文
共 50 条
  • [21] Increased DNA methyltransferase contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP
    Ma, L.
    Yang, R.
    Zhou, Z.
    Zhou, H.
    Wang, H.
    Li, H.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 539 - 540
  • [22] CD70/CD27 Signaling Promotes Expansion of Clonal Plasma Cells in Multiple Myeloma and Is a Promising Therapeutic Target in Advanced Disease
    Forster, Stefan
    Bachmann, Chantal
    Boy, Maxime
    Radpour, Ramin
    Schuerch, Christian M.
    Bruhl, Frido
    Riether, Carsten
    Ochsenbein, Adrian
    BLOOD, 2023, 142
  • [23] The Role of CD70 in Vascular Function
    Itani, Hana A.
    Pandey, Arvind
    Brown, Jonathan D.
    Harrison, David G.
    FASEB JOURNAL, 2017, 31
  • [24] CD70 expression in thymic carcinoma
    Hishima, T
    Fukayama, M
    Hayashi, Y
    Fujii, T
    Ooba, T
    Funata, N
    Koike, M
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2000, 24 (05) : 742 - 746
  • [25] The Role of CD70 in Vascular Function
    Itani, Hana A.
    Pandey, Arvind
    Brown, Jonathan D.
    Harrison, David G.
    HYPERTENSION, 2016, 68
  • [26] Immune escape for renal cell carcinoma: CD70 mediates apoptosis in lymphocytes
    Diegmann, Julia
    Junker, Kerstin
    Loncarevic, Ivan F.
    Michel, Susanne
    Schimmel, Bettina
    von Eggeling, Ferdinand
    NEOPLASIA, 2006, 8 (11): : 933 - 938
  • [27] CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors
    Held-Feindt, J
    Mentlein, R
    INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (03) : 352 - 356
  • [28] Increased expressions of DNA methyltransferases contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP
    Ma, Li
    Zhou, Zeping
    Wang, Hongmei
    Zhou, Hu
    Zhang, Donglei
    Li, Huiyuan
    Qi, Aiping
    Yang, Renchi
    MOLECULAR IMMUNOLOGY, 2011, 48 (12-13) : 1525 - 1531
  • [29] Therapeutic targeting of CD70 and CD27
    Wajant, Harald
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2016, 20 (08) : 959 - 973
  • [30] CD70 Expression in Mature T and NK Cell Neoplasms: A Potential Therapeutic Target
    Wang, Linlin
    Ai, Weiyun
    Gill, Ryan
    LABORATORY INVESTIGATION, 2015, 95 : 384A - 384A