Hidden role of microglia during neurodegenerative disorders and neurocritical care: A mitochondrial perspective

被引：1

作者：

Wang, Xinrun ^{[1
]}

Hu, Jiyun ^{[1
]}

Xie, Shucai ^{[1
]}

Li, Wenchao ^{[1
]}

Zhang, Haisong ^{[1
]}

Huang, Li ^{[1
]}

Qian, Zhaoxin ^{[1
]}

Zhao, Chunguang ^{[1
]}

Zhang, Lina ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Hunan Prov Clin Res Ctr Crit Care Med, Natl Clin Res Ctr Geriatr Disorders,Dept Crit Care, Changsha 410008, Hunan, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 142卷

基金：

中国国家自然科学基金;

关键词：

Microglia; Mitochondrial; Neurodegenerative disorders; Neurocritical care; Energy metabolism; Mitophagy; TRAUMATIC BRAIN-INJURY; MULTIPLE-SCLEROSIS; ACTIVATION; STROKE; NEUROINFLAMMATION; SURVEILLANCE; PHAGOCYTOSIS; PATHOGENESIS; INFLAMMATION; DYSFUNCTION;

D O I：

10.1016/j.intimp.2024.113024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The incidence of aging-related neurodegenerative disorders and neurocritical care diseases is increasing worldwide. Microglia, the main inflammatory cells in the brain, could be potential viable therapeutic targets for treating neurological diseases. Interestingly, mitochondrial functions, including energy metabolism, mitophagy and transfer, fission and fusion, and mitochondrial DNA expression, also change in activated microglia. Notably, mitochondria play an active and important role in the pathophysiology of neurodegenerative disorders and neurocritical care diseases. This review briefly summarizes the current knowledge on mitochondrial dysfunction in microglia in neurodegenerative disorders and neurocritical care diseases and comprehensively discusses the prospects of the application of neurological injury prevention and treatment targets by mitochondria.

引用

页数：15

共 22 条

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