Associations between acute and chronic graft-versus-host disease

被引：0

作者：

Tamaki, Masaharu ^{[1
,2
]}

Akahoshi, Yu ^{[1
,3
]}

Inamoto, Yoshihiro ^{[4
]}

Morita, Kaoru ^{[5
]}

Uchida, Naoyuki ^{[6
]}

Doki, Noriko ^{[7
]}

Tanaka, Masatsugu ^{[8
]}

Nishida, Tetsuya ^{[9
]}

Ohigashi, Hiroyuki ^{[10
]}

Nakamae, Hirohisa ^{[11
]}

Onizuka, Makoto ^{[12
]}

Katayama, Yuta ^{[13
,14
]}

Matsuoka, Ken-ichi ^{[15
]}

Sawa, Masashi ^{[16
]}

Ishimaru, Fumihiko ^{[17
]}

Kanda, Yoshinobu ^{[1
,5
]}

Fukuda, Takahiro ^{[18
]}

Atsuta, Yoshiko ^{[19
,20
]}

Terakura, Seitaro ^{[21
]}

Kanda, Junya ^{[22
]}

机构：

[1] Jichi Med Univ, Saitama Med Ctr, Div Hematol, 1-847 Amanuma Cho,Omiya Ku, Saitama 3308503, Japan

[2] Jichi Med Univ, Ctr Mol Med, Div Emerging Med Integrated Therapeut, Shimotsuke, Japan

[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol Med Oncol, New York, NY USA

[4] Fujita Hlth Univ, Sch Med, Dept Bone & Marrow Transplantat & Cellular Therapy, Toyoake, Japan

[5] Jichi Med Univ, Div Hematol, Shimotsuke, Japan

[6] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Toranomon Hosp, Dept Hematol, Tokyo, Japan

[7] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Hematol Div, Tokyo, Japan

[8] Kanagawa Canc Ctr, Dept Hematol, Yokohama, Japan

[9] Nagoya Daiichi Hosp, Japanese Red Cross Aichi Med Ctr, Dept Hematol, Nagoya, Japan

[10] Hokkaido Univ Hosp, Dept Hematol, Sapporo, Japan

[11] Osaka Metropolitan Univ Hosp, Dept Hematol, Osaka, Japan

[12] Tokai Univ, Sch Med, Dept Hematol Oncol, Isehara, Japan

[13] Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan

[14] Atom bomb Survivors Hosp, Hiroshima, Japan

[15] Okayama Univ Hosp, Dept Hematol & Oncol, Okayama, Japan

[16] Anjo Kosei Hosp, Dept Hematol & Oncol, Anjo, Japan

[17] Japanese Red Cross Soc Blood Serv Headquarters, Tech Dept, Tokyo, Japan

[18] Natl Canc Ctr, Dept Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[19] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagakute, Japan

[20] Aichi Med Univ, Sch Med, Dept Registry Sci Transplant & Cellular Therapy, Nagakute, Japan

[21] Nagoya Univ, Grad Sch Med, Dept Hematol & Oncol, Nagoya, Japan

[22] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

来源：

BLOOD ADVANCES | 2024年 / 8卷 / 16期

关键词：

HEMATOPOIETIC-CELL TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; BONE-MARROW-TRANSPLANTATION; UMBILICAL-CORD BLOOD; RISK-FACTORS; CHRONIC GVHD; NONRELAPSE MORTALITY; INTERNATIONAL BLOOD; CLINICAL-TRIALS; ORGAN INVOLVEMENT;

D O I：

10.1182/bloodadvances.2024013442

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic graft-versus-host disease (GVHD) is 1 of the major complications after allogeneic hematopoietic cell transplantation (allo-HCT). Although various risk factors for chronic GVHD have been reported, limited data are available regarding the impact of acute GVHD on chronic GVHD. We examined the association between acute and chronic GVHD using a Japanese registry data set. The landmark point was set at day 100 after allo-HCT, and patients who died or relapsed before the landmark point were excluded. In total, 14 618 and 6135 patients who underwent allo-HCT with bone marrow or peripheral blood (BM/PB) and with umbilical cord blood (UCB), respectively, were analyzed. In the BM/PB cohort, the risk for chronic GVHD that requires systemic steroids increased with each increase in acute GVHD grade from 0 to 2 (grade 0 vs 1 [hazard ratio (HR), 1.32; 95% confidence interval (CI), 1.19-1.46; P < .001]; grade 1 vs 2 [HR, 1.41; 95% CI, 1.28-1.56; P < .001]), but the risk was similar between acute GVHD grade 2 and grade 3 to 4 (HR, 1.02; 95% CI, 0.91-1.15; P = 1.0). These findings were confirmed in the UCB cohort. We further observed that the risk for severe chronic GVHD increased with each increment in the grade of acute GVHD, even between acute GVHD grade 2 and grade 3 to (grade 2 vs 3-4: HR, 1.70; 95% CI, 1.12-2.58; P = .025). In conclusion, the preceding profiles of acute GVHD should help to stratify the risk for chronic GVHD and its severity, which might be useful for the development of riskadopted preemptive strategies for chronic GVHD.

引用

页码：4250 / 4261

页数：12

共 69 条

[11] Post-Transplantation CyclophosphamideBased Graft-versus-Host Disease Prophylaxis [J].

Bolanos-Meade, J. ;

Hamadani, M. ;

Wu, J. ;

Al Malki, M. M. ;

Martens, M. J. ;

Runaas, L. ;

Elmariah, H. ;

Rezvani, A. R. ;

Gooptu, M. ;

Larkin, K. T. ;

Shaffer, B. C. ;

El Jurdi, N. ;

Loren, A. W. ;

Solh, M. ;

Hall, A. C. ;

Alousi, A. M. ;

Jamy, O. H. ;

Perales, M. -A. ;

Yao, J. M. ;

Applegate, K. ;

Bhatt, A. S. ;

Kean, L. S. ;

Efebera, Y. A. ;

Reshef, R. ;

Clark, W. ;

DiFronzo, N. L. ;

Leifer, E. ;

Horowitz, M. M. ;

Jones, R. J. ;

Holtan, S. G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (25) :2338-2348

[12] Impact of Chronic Graft-versus-Host Disease on Late Relapse and Survival on 7,489 Patients after Myeloablative Allogeneic Hematopoietic Cell Transplantation for Leukemia [J].

Boyiadzis, Michael ;

Arora, Mukta ;

Klein, John P. ;

Hassebroek, Anna ;

Hemmer, Michael ;

Urbano-Ispizua, Alvaro ;

Antin, Joseph H. ;

Bolwell, Brian J. ;

Cahn, Jean-Yves Y. ;

Cairo, Mitchell S. ;

Cutler, Corey S. ;

Flowers, Mary E. ;

Gale, Robert P. ;

Herzig, Roger ;

Isola, Luis M. ;

Jacobsohn, David A. ;

Jagasia, Madan H. ;

Klumpp, Thomas R. ;

Lee, Stephanie J. ;

Petersdorf, Effie W. ;

Santarone, Stella ;

Spellman, Stephen R. ;

Schouten, Harry C. ;

Verdonck, Leo F. ;

Wingard, John R. ;

Weisdorf, Daniel J. ;

Horowitz, Mary M. ;

Pavletic, Steven Z. .

CLINICAL CANCER RESEARCH, 2015, 21 (09) :2020-2028

[13] Risk factors for chronic graft-versus-host disease after bone marrow transplantation:: a retrospective single centre analysis [J].

Carlens, S ;

Ringdén, O ;

Remberger, M ;

Lönnqvist, B ;

Hägglund, H ;

Klaesson, S ;

Mattsson, J ;

Svahn, BM ;

Winiarski, J ;

Ljungman, P ;

Aschan, J .

BONE MARROW TRANSPLANTATION, 1998, 22 (08) :755-761

[14] Antithymocyte Globulin for Matched Sibling Donor Transplantation in Patients With Hematologic Malignancies: A Multicenter, Open-Label, Randomized Controlled Study [J].

Chang, Ying-Jun ;

Wu, De-Pei ;

Lai, Yong-Rong ;

Liu, Qi-Fa ;

Sun, Yu-Qian ;

Hu, Jiong ;

Hu, Yu ;

Zhou, Jian-Feng ;

Li, Juan ;

Wang, Shun-Qing ;

Li, Wei ;

Du, Xin ;

Lin, Dong-Jun ;

Ren, Han-Yun ;

Chen, Fang-Pin ;

Li, Yu-Hua ;

Zhang, Xi ;

Huang, He ;

Song, Yong-Ping ;

Jiang, Ming ;

Hu, Jian-Da ;

Liang, Ying-Min ;

Wang, Jing-Bo ;

Xiao, Yang ;

Huang, Xiao-Jun .

JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (29) :3367-3376

[15] GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes [J].

Chen, Y-B ;

Wang, T. ;

Hemmer, M. T. ;

Brady, C. ;

Couriel, D. R. ;

Alousi, A. ;

Pidala, J. ;

Urbano-Ispizua, A. ;

Choi, S. W. ;

Nishihori, T. ;

Teshima, T. ;

Inamoto, Y. ;

Wirk, B. ;

Marks, D. I. ;

Abdel-Azim, H. ;

Lehmann, L. ;

Yu, L. ;

Bitan, M. ;

Cairo, M. S. ;

Qayed, M. ;

Salit, R. ;

Gale, R. P. ;

Martino, R. ;

Jaglowski, S. ;

Bajel, A. ;

Savani, B. ;

Frangoul, H. ;

Lewis, I. D. ;

Storek, J. ;

Askar, M. ;

Kharfan-Dabaja, M. A. ;

Aljurf, M. ;

Ringden, O. ;

Reshef, R. ;

Olsson, R. F. ;

Hashmi, S. ;

Seo, S. ;

Spitzer, T. R. ;

MacMillan, M. L. ;

Lazaryan, A. ;

Spellman, S. R. ;

Arora, M. ;

Cutler, C. S. .

BONE MARROW TRANSPLANTATION, 2017, 52 (03) :400-408

[16] THYMIC ATROPHY AND REGROWTH IN RESPONSE TO CHEMOTHERAPY - CT EVALUATION [J].

CHOYKE, PL ;

ZEMAN, RK ;

GOOTENBERG, JE ;

GREENBERG, JN ;

HOFFER, F ;

FRANK, JA .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1987, 149 (02) :269-272

[17] Age Related Differences in the Biology of Chronic Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation [J].

Cuvelier, Geoff D. E. ;

Li, Amanda ;

Drissler, Sibyl ;

Kariminia, Amina ;

Abdossamadi, Sayeh ;

Rozmus, Jacob ;

Chanoine, Jean-Pierre ;

Ng, Bernard ;

Mostafavi, Sara ;

Brinkman, Ryan R. ;

Schultz, Kirk R. .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[18] Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria [J].

Cuvelier, Geoffrey D. E. ;

Nemecek, Eneida R. ;

Wahlstrom, Justin T. ;

Kitko, Carrie L. ;

Lewis, Victor A. ;

Schechter, Tal ;

Jacobsohn, David A. ;

Harris, Andrew C. ;

Pulsipher, Michael A. ;

Bittencourt, Henrique ;

Choi, Sung Won ;

Caywood, Emi H. ;

Kasow, Kimberly A. ;

Bhatia, Monica ;

Oshrine, Benjamin R. ;

Flower, Allyson ;

Chaudhury, Sonali ;

Coulter, Donald ;

Chewning, Joseph H. ;

Joyce, Michael ;

Savasan, Sureyya ;

Pawlowska, Anna B. ;

Megason, Gail C. ;

Mitchell, David ;

Cheerva, Alexandra C. ;

Lawitschka, Anita ;

West, Lori J. ;

Pan, Bo ;

Al Hamarneh, Yazid N. ;

Halevy, Anat ;

Schultz, Kirk R. .

BLOOD, 2019, 134 (03) :304-316

[19] Current Use of and Trends in Hematopoietic Cell Transplantation in the United States [J].

D'Souza, Anita ;

Fretham, Caitrin ;

Lee, Stephanie J. ;

Arora, Mukta ;

Brunner, Janet ;

Chhabra, Saurabh ;

Devine, Steven ;

Eapen, Mary ;

Hamadani, Mehdi ;

Hari, Parameswaran ;

Pasquini, Marcelo C. ;

Perez, Waleska ;

Phelan, Rachel A. ;

Riches, Marcie L. ;

Rizzo, J. Douglas ;

Saber, Wael ;

Shaw, Bronwen E. ;

Spellman, Stephen R. ;

Steinert, Patricia ;

Weisdorf, Daniel J. ;

Horowitz, Mary M. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (08) :E177-E182

[20] Nonrelapse mortality among patients diagnosed with chronic GVHD: an updated analysis from the Chronic GVHD Consortium [J].

DeFilipp, Zachariah ;

Alousi, Amin M. ;

Pidala, Joseph A. ;

Carpenter, Paul A. ;

Onstad, Lynn E. ;

Arai, Sally ;

Arora, Mukta ;

Cutler, Corey S. ;

Flowers, Mary E. D. ;

Kitko, Carrie L. ;

Chen, George L. ;

Lee, Stephanie J. ;

Hamilton, Betty K. .

BLOOD ADVANCES, 2021, 5 (20) :4278-4284

← 1 2 3 4 5 6 7 →