Targeting Epigenetic Vulnerabilities of Cancer Cells by Exploiting Chromatin Structure and Chemistry

被引：0

作者：

Adhireksan, Zenita ^{[1
]}

Davey, Gabriela E. ^{[1
]}

Ma, Zhujun ^{[1
]}

Palermo, Giulia ^{[2
]}

Riedel, Tina ^{[2
]}

Murray, Benjamin S. ^{[3
]}

Nazarov, Alexey A. ^{[4
]}

Hartinger, Christian G. ^{[5
]}

Rothlisberger, Ursula

Dyson, Paul J. ^{[2
]}

Davey, Curt A. ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[3] Univ Hull, Dept Chem, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England

[4] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[5] Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 1142, New Zealand

来源：

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2016年 / 72卷

关键词：

chromatin; nucleosome; metal based compound; anticancer drug;

D O I：

10.1107/S2053273316096935

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

MS5-P3

引用

页码：S204 / S205

页数：2

共 3 条

[1] Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity [J].

Adhireksan, Zenita ;

Davey, Gabriela E. ;

Campomanes, Pablo ;

Groessl, Michael ;

Clavel, Catherine M. ;

Yu, Haojie ;

Nazarov, Alexey A. ;

Yeo, Charmian Hui Fang ;

Ang, Wee Han ;

Droege, Peter ;

Rothlisberger, Ursula ;

Dyson, Paul J. ;

Davey, Curt A. .

NATURE COMMUNICATIONS, 2014, 5

[2] Exposure to Metals Can Be Therapeutic [J].

Davey, Curt A. .

CHIMIA, 2015, 69 (03) :125-130

[3] A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core [J].

Wu, Bin ;

Ong, Michelle S. ;

Groessl, Michael ;

Adhireksan, Zenita ;

Hartinger, Christian G. ;

Dyson, Paul J. ;

Davey, Curt A. .

CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (13) :3562-3566

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