A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms

被引：1

作者：

Hoff, Camilla O. ^{[1
]}

Manzi, Joao ^{[1
]}

Ferreira, Raphaella ^{[2
]}

Chauhan, Aman ^{[3
]}

Housein, Peter ^{[3
]}

Merchant, Nipun ^{[3
]}

Livingstone, Alan ^{[3
]}

Vianna, Rodrigo ^{[2
]}

Abreu, Phillipe ^{[4
]}

机构：

[1] Univ Sao Paulo, Sao Paulo Med Sch, Sao Paulo, Brazil

[2] Univ Miami, Jackson Mem Hosp, Miami Transplant Inst, Miami, FL USA

[3] Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA

[4] Univ Colorado, Div Transplant Surg, Anschutz Med Campus, Aurora, CO USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 203卷

关键词：

Liver transplant; Oncology; Neuroendocrine tumors; Biomarkers; CIRCULATING TUMOR-CELLS; NEURON-SPECIFIC ENOLASE; PROGRESSION-FREE SURVIVAL; PLASMA CHROMOGRANIN-A; PROGNOSTIC MARKERS; PANCREATIC-CANCER; FOLLOW-UP; MICRORNA EXPRESSION; CLINICAL UTILITY; HIGH-GRADE;

D O I：

10.1016/j.critrevonc.2024.104460

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroendocrine neoplasms (NENs) arise from neuroendocrine cells in a wide variety of organs. One of the most affected disease sites is the gastrointestinal system, which originates the gastro-entero-pancreatic NENs (GEPNENs), a heterogenous group of malignancies that are rapidly increasing in incidence. These tumors can be functioning, with secretory activity leading to identifiable clinical syndromes, or non-functioning, with no secretory activity but with local symptoms of tumor growth and metastasis. A limitation in biomarkers is a crucial unmet need in non-secretory NEN management, as clinical decision-making is made more difficult by obstacles in tumor classification, prognostic evaluation, assessment of treatment response and surveillance. The objective of this review is to present existing and novel biomarkers for NENs that can function as prognostic factors and monitor disease progression or regression longitudinally, with a special emphasis on innovative research into novel multianalyte biomarkers.

引用

页数：12

共 121 条

[81] Molecular Genomic Blood Biomarkers for Neuroendocrine Tumors: The Long and Winding Road from Berzelius and Bence Jones to a Neuroendocrine Destination [J].

Oberg, Kjell .

NEUROENDOCRINOLOGY, 2021, 111 (04) :297-303

[82] Consensus on biomarkers for neuroendocrine tumour disease [J].

Oberg, Kjell ;

Modlin, Irvin M. ;

De Herder, Wouter ;

Pavel, Marianne ;

Klimstra, David ;

Frilling, Andrea ;

Metz, David C. ;

Heaney, Anthony ;

Kwekkeboom, Dik ;

Strosberg, Jonathan ;

Meyer, Timothy ;

Moss, Steven F. ;

Washington, Kay ;

Wolin, Edward ;

Liu, Eric ;

Goldenring, James .

LANCET ONCOLOGY, 2015, 16 (09) :E435-E446

[83] Circulating biomarkers in gastroenteropancreatic neuroendocrine tumours [J].

Oberg, Kjell .

[84] Evaluating gastroenteropancreatic neuroendocrine tumors through microRNA sequencing [J].

Panarelli, Nicole ;

Tyryshkin, Kathrin ;

Wong, Justin Jong Mun ;

Majewski, Adrianna ;

Yang, Xiaojing ;

Scognamiglio, Theresa ;

Kim, Michelle Kang ;

Bogardus, Kimberly ;

Tuschl, Thomas ;

Chen, Yao-Tseng ;

Renwick, Neil .

[85] Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors [J].

Panzuto, F ;

Severi, C ;

Cannizzaro, R ;

Falconi, M ;

Angeletti, S ;

Pasquali, A ;

Corleto, VD ;

Annibale, B ;

Buonadonna, A ;

Pederzoli, P ;

Delle Fave, G .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2004, 27 (01) :6-11

[86] Circulating Neuroendocrine Gene Transcripts (NETest): A Postoperative Strategy for Early Identification of the Efficacy of Radical Surgery for Pancreatic Neuroendocrine Tumors [J].

Partelli, Stefano ;

Andreasi, Valentina ;

Muffatti, Francesca ;

Lena, Marco Schiavo ;

Falconi, Massimo .

ANNALS OF SURGICAL ONCOLOGY, 2020, 27 (10) :3928-3936

[87] NET Blood Transcript Analysis Defines the Crossing of the Clinical Rubicon: When Stable Disease Becomes Progressive [J].

Pavel, Marianne ;

Jann, Henning ;

Prasad, Vikas ;

Drozdov, Ignat ;

Modlin, Irvin M. ;

Kidd, Mark .

NEUROENDOCRINOLOGY, 2017, 104 (02) :170-182

[88] Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas [J].

Pavel, ME ;

Hassler, G ;

Baum, U ;

Hahn, EG ;

Lohmann, T ;

Schuppan, D .

CLINICAL ENDOCRINOLOGY, 2005, 62 (04) :434-443

[89] Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cell lesions and gastric carcinoids [J].

Peracchi, M ;

Gebbia, C ;

Basilisco, G ;

Quatrini, M ;

Tarantino, C ;

Vescarelli, C ;

Massironi, S ;

Conte, D .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 152 (03) :443-448

[90] NETest: a systematic review focusing on the prognostic and predictive role [J].

Puliani, G. ;

Di Vito, V. ;

Feola, T. ;

Sesti, F. ;

Centello, R. ;

Pandozzi, C. ;

Tarsitano, M. G. ;

Verrico, M. ;

Lenzi, A. ;

Isidori, A. M. ;

Giannetta, E. ;

Faggiano, A. .

NEUROENDOCRINOLOGY, 2022, 112 (06) :523-536

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