Interweaving the Numerical harmonic symmetry principles of the K plus Pore ion channel momentum

被引:1
作者
Ben-Abu, Yuval [1 ,2 ]
机构
[1] Sapir Acad Coll, Phys Unit, IL-79165 Sderot, Hof Ashkelon, Israel
[2] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England
关键词
Symmetrical energy principles momentum; Symmetric and asymmetric ion collisions; POTASSIUM CHANNELS;
D O I
10.1016/j.neuint.2024.105797
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
K+ + channels exist in all living systems. They allow a selective transition to the K+ + ion, which enables the activity of various vital tissues such as muscle cells, neurons, and even bacteria and plants. Despite the mechanism variation in the gating process of K+ + channels in different tissues, the selectivity for the K+ + ion is preserved and the electrochemical cascade is maintained in these tissues. The electrochemical gradient of the K+ + ion is very close to the diffusion rate of K+ + ions in bulk water. On the molecular level, how does a K+ + ion move across the ion conduction pathway? There are many molecular models that describe and answer this question, however, this is rarely described on the macro level. Here, a physical model can serve as a very good basis for enabling a deeper understanding of the K+ + ion for ion transport. Classical physical energy and linear and angular momentum laws can provide a good explanation as to how and what happens to K+ + ions when they pass through an ion conduction pathway. This model describes the passage of the ion even before it enters the ion conduction path until the last ion at the end exits. The simulation described here is fascinating and depicts the state of the ion at the farthest end released at almost the same speed as the first ion initially, while all the other ions remain almost at rest. How does this occur? What happens if we change the size or mass of the ion? In this work, I describe this principle and the related problems that could be studied.
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页数:5
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