Umbrella Review on the Relationship between Vitamin D Levels and Cancer

被引:2
作者
Schoemann-Finck, Matthias [1 ]
Reichrath, Joerg [2 ]
机构
[1] German Univ Appl Sci Prevent & Hlth Management, D-66123 Saarbrucken, Germany
[2] Saarland Univ Hosp, Dept Dermatol, D-66421 Homburg, Germany
关键词
cancer; umbrella review; 25(OH)D status; vitamin D; vitamin D status; pancreatic cancer; breast cancer; lung cancer; prostate cancer; colorectal carcinoma; CIRCULATING 25-HYDROXYVITAMIN D; DOSE-RESPONSE METAANALYSIS; COLORECTAL-CANCER; PROSTATE-CANCER; BREAST-CANCER; D SUPPLEMENTATION; LUNG-CANCER; PANCREATIC-CANCER; RISK; ASSOCIATION;
D O I
10.3390/nu16162720
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Cancer is a growing public health problem and cancer is linked to vitamin D via several mechanisms. Recent umbrella reviews on the extra-skeletal effects of vitamin D did not turn their attention to cancer. Accordingly, an overview of the current state of research is needed. Materials and methods: An umbrella review was conducted to provide an overview of systematic reviews on the association between vitamin D and incidence or mortality of breast cancer, colorectal cancer, lung cancer, pancreatic cancer, and prostate cancer. Results: Inverse correlations were found between the vitamin D level (measured by circulating 25(OH)D) and mortality for all five types of cancer. For breast cancer, colorectal cancer, lung cancer, and pancreatic cancer, there are also hints of a lower incidence due to higher 25(OH)D levels. Conclusion: As most reviews include observational studies, conclusions on causality cannot be made. Methodological differences between the included reviews and different study designs in the individual studies lead to methodological problems. Despite these problems, the review shows inverse correlations between 25(OH)D levels and mortality, and mostly inverse correlations between 25(OH)D levels and incidence.
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页数:11
相关论文
共 78 条
[1]   Serum 25-Hydroxy Vitamin D and Prostate Cancer Risk in a Large Nested Case-Control Study [J].
Albanes, Demetrius ;
Mondul, Alison M. ;
Yu, Kai ;
Parisi, Dominick ;
Horst, Ronald L. ;
Virtamo, Jarmo ;
Weinstein, Stephanie J. .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2011, 20 (09) :1850-1860
[2]   Vitamin D deficiency 2.0: an update on the current status worldwide [J].
Amrein, Karin ;
Scherkl, Mario ;
Hoffmann, Magdalena ;
Neuwersch-Sommeregger, Stefan ;
Koestenberger, Markus ;
Berisha, Adelina Tmava ;
Martucci, Gennaro ;
Pilz, Stefan ;
Malle, Oliver .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2020, 74 (11) :1498-1513
[3]  
[Anonymous], 2009, Oxford Centre for Evidence-Based Medicine Levels of Evidence
[4]  
Autier P, 2017, LANCET DIABETES ENDO, V5, P986, DOI [10.1016/S2213-8587(17)30357-1, 10.1016/s2213-8587(17)30357-1]
[5]   Vitamin D status and ill health: a systematic review [J].
Autier, Philippe ;
Boniol, Mathieu ;
Pizot, Cecile ;
Mullie, Patrick .
LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (01) :76-89
[6]   The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences [J].
Bandera Merchan, Borja ;
Morcillo, Sonsoles ;
Martin-Nunez, Gracia ;
Jose Tinahones, Francisco ;
Macias-Gonzalez, Manuel .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 167 :203-218
[7]  
Biondi-Zoccai G., 2016, Umbrella Reviews: Evidence Synthesis with Overviews of Reviews and Meta-Epidemiologic Studies, DOI [DOI 10.1007/978-3-319-25655-9, 10.1007/978-3-319-25655-9]
[8]  
Bischoff-Ferrari H.A., 2020, Der Internist, V61, P1196, DOI [10.1007/s00108-020-00869-y, DOI 10.1007/S00108-020-00869-Y]
[9]   Prognostic Role of Vitamin D Status and Efficacy of Vitamin D Supplementation in Cancer Patients: A Systematic Review [J].
Buttigliero, Consuelo ;
Monagheddu, Chiara ;
Petroni, Paola ;
Saini, Andrea ;
Dogliotti, Luigi ;
Ciccone, Giovannino ;
Berruti, Alfredo .
ONCOLOGIST, 2011, 16 (09) :1215-1227
[10]   Vitamin D Receptor Signaling and Cancer [J].
Campbell, Moray J. ;
Trump, Donald L. .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2017, 46 (04) :1009-1038