Dimethyl 4-(4-ethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

被引：4

作者：

Fun, Hoong-Kun ^{[1
]}

Quah, Ching Kheng ^{[1
]}

Reddy, B. Palakshi ^{[2
]}

Sarveswari, S. ^{[2
]}

Vijayakumar, V. ^{[2
]}

机构：

[1] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, George Town 11800, Malaysia

[2] VIT Univ, Sch Sci & Humanities, Div Organ Chem, Vellore 632014, Tamil Nadu, India

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷

关键词：

1,4-DIHYDROPYRIDINES; DERIVATIVES; ANTAGONISTS;

D O I：

10.1107/S1600536809033364

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title molecule, C19H23NO5, the dihedral angle formed by the benzene ring and the planar part of the dihydropyridine ring is 83.52 (5)degrees. The dihydropyridine ring adopts a flattened boat conformation. In the crystal, molecules are linked by N-H center dot center dot center dot O hydrogen bonds, generating chains running parallel to [100]. The crystal structure is consolidated by C-H center dot center dot center dot O contacts.

引用

页码：O2255 / U2929

页数：12

共 13 条

[1] PATTERNS IN HYDROGEN BONDING - FUNCTIONALITY AND GRAPH SET ANALYSIS IN CRYSTALS [J].

BERNSTEIN, J ;

DAVIS, RE ;

SHIMONI, L ;

CHANG, NL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1995, 34 (15) :1555-1573

[2]

BOCKER RH, 1986, J MED CHEM, V29, P1596

[3]

Bruker, 2005, APEX2 SAINT SADABS

[4] 1,4-DIHYDROPYRIDINES AS ANTAGONISTS OF PLATELET-ACTIVATING-FACTOR .1. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-(4-HETEROCYCLYL)PHENYL DERIVATIVES [J].

COOPER, K ;

FRAY, MJ ;

PARRY, MJ ;

RICHARDSON, K ;

STEELE, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (17) :3115-3129

[5] A NITROGEN-GAS-STREAM CRYOSTAT FOR GENERAL X-RAY-DIFFRACTION STUDIES [J].

COSIER, J ;

GLAZER, AM .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1986, 19 (02) :105-107

[6] GENERAL DEFINITION OF RING PUCKERING COORDINATES [J].

CREMER, D ;

POPLE, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1354-1358

[7] Diethyl 4-(4-ethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate [J].

Fun, Hoong-Kun ;

Goh, Jia Hao ;

Reddy, B. Palakshi ;

Sarveswari, S. ;

Vijayakumar, V. .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 :O2247-U2859

[8] QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL ANTAGONISTS (NIFEDIPINE ANALOGS) - A QUANTUM CHEMICAL/CLASSICAL APPROACH [J].

GAUDIO, AC ;

KOROLKOVAS, A ;

TAKAHATA, Y .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (08) :1110-1115

[9] Approaches to combinatorial synthesis of heterocycles: A solid-phase synthesis of 1,4-dihydropyridines [J].

Gordeev, MF ;

Patel, DV ;

Gordon, EM .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (03) :924-928

[10] A short history of SHELX [J].

Sheldrick, George M. .

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122

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