Revisiting the Clinical Interpretation of CT-Measured Pulmonary Artery-to-Aorta Ratio-The Rotterdam Study

被引：0
作者：
Khan, C. F. [1 ,2 ]
Ikram, M. Kamran [1 ,2 ]
Terzikhan, Natalie [1 ]
Brusselle, Guy G. [1 ,3 ,4 ]
Bos, Daniel [1 ,4 ,5 ,6 ]
机构：
[1] Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands
[2] Erasmus MC, Dept Radiol & Nucl Med, Univ Med Ctr, Rotterdam, Netherlands
[3] Erasmus MC, Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
[4] Erasmus MC, Univ Med Ctr, Dept Resp Med, Rotterdam, Netherlands
[5] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium
[6] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
来源：
ACADEMIC RADIOLOGY | 2024年 / 31卷 / 09期
关键词：
Pulmonary artery diameter; Aorta diameter; PA; A ratio; Rotterdam Study; Computed tomography; COMPUTED-TOMOGRAPHY; REFERENCE VALUES; DIAMETER RATIO; EXACERBATIONS; DETERMINANTS; HYPERTENSION; ENLARGEMENT; FAILURE; UPDATE;
D O I：
10.1016/j.acra.2024.03.037
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Rationale: The pulmonary artery (PA) diameter-to-aorta ratio (PA:A) ratio is a novel marker in cardiovascular imaging for detecting pulmonary hypertension. However, we question the effect of the varying aorta diameter on the ratio, which complicates the interpretation of the PA:A ratio. Objective: Investigate the variability of the PA:A ratio by examining the correlation between PA:A ratio and aorta diameter and by comparing the associations of the PA diameter, aorta diameters, and PA:A ratio. Methods: We included 2197 participants from the Rotterdam Study who underwent non-contrast multidetector computed tomography to measure the PA and aorta diameters. Pearson correlation coefficient was calculated between the PA:A ratio and aorta diameter. Multiple linear regression analyses were performed to compare the determinants of the individual diameters and PA:A ratio. Results: We found a statistically significant correlation between the PA:A ratio and aorta diameter (r = -0.38, p < 0.001). The PA diameter was statistically significantly associated with, height, weight, diastolic blood pressure, blood pressure medication, prevalence of atrial fibrillation, prevalence of heart failure, and prevalence of stroke (p < 0.05). Except for blood pressure medication, the PA:A ratio had similar determinants compared to the PA diameter but was also statistically significantly associated with sex, and systolic blood pressure (p < 0.05), which were statistically significantly associated with the aorta diameter (p < 0.05). Conclusion: The PA:A ratio should not be interpreted without taking into account the variability of the individual components (PA and aorta diameter) according to the anthropomorphic and clinical characteristics.
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页码：3837 / 3843
页数：7
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