Prognostic Value of Plasma Immunoglobulin G N-Glycome Traits in Pulmonary Arterial Hypertension

被引:5
|
作者
Zhang, Ze-Jian [1 ]
Liu, Chao [2 ]
Ma, Jie-Ling [3 ]
Ma, Jing-Si [4 ]
Wang, Jia [5 ]
Li, Ruo-Nan [4 ]
Lu, Dan [6 ]
Zhou, Yu-Ping [3 ]
Lian, Tian-Yu [2 ]
Zhang, Si-Jin [2 ]
Li, Jing-Hui [7 ,8 ]
Wang, Lan [9 ]
Sun, Kai [1 ]
Cheng, Chun-Yan [2 ]
Wu, Wen-Hui [9 ]
Jiang, Xin [2 ]
Jing, Zhi-Cheng [2 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
[2] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci,Dept Cardiol, 106,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Cardiol, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
[4] Henan Univ, Sch Pharm, Kaifeng, Peoples R China
[5] Weifang Med Univ, Dept Med Lab, Weifang, Peoples R China
[6] Peking Univ, Aerosp Ctr Hosp, Aerosp Sch Clin Med, Cardiac Dept, Beijing, Peoples R China
[7] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Cardiovasc Dis, Beijing, Peoples R China
[8] Chinese Acad Med Sci & Peking Union MedicalCollege, FuWai Hosp, Beijing, Peoples R China
[9] Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Cardiopulm Circulat, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
KEY WORDS biomarker; fucosylation; IgG N-glycans; pulmonary arterial hypertension; risk stratification; SERUM IGG GALACTOSYLATION; LONG-TERM SURVIVAL; C-REACTIVE PROTEIN; GLYCOSYLATION; DIAGNOSIS; BIOMARKER; STRATEGY;
D O I
10.1016/j.jacc.2024.05.077
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide is the only blood biomarker in established risk calculators for pulmonary arterial hypertension (PAH). Profiling systemic-originated plasma immunoglobulin G (IgG) N-glycans, which reflect different components of the pathophysiology of PAH including immune dysregulation and inflammation, may improve PAH risk assessment. Objectives This study sought to identify plasma IgG N-glycan biomarkers that predict survival in PAH to improve risk assessment. Methods This cohort study examined 622 PAH patients from 2 national centers (Beijing [discovery] cohort: n = 273; Shanghai [validation] cohort: n = 349). Plasma IgG N-glycomes were profiled by a robust mass spectrometry-based method. Prognostic IgG N-glycan traits were identified and validated in the 2 cohorts using Cox regression and Kaplan-Meier survival analyses. The added value of IgG N-glycan traits to previously established risk models was assessed using Harrell C-indexes and survival analysis. Results Plasma IgG fucosylation was found to predict survival independent of age and sex in the discovery cohort (HR: 0.377; 95% CI: 0.168-0.845; P = 0.018) with confirmation in the validation cohort (HR: 0.445; 95% CI: 0.264-0.751; P = 0.005). IgG fucosylation remained a robust predictor of mortality in combined cohorts after full adjustment and in subgroup analyses. Integrating IgG fucosylation into previously established risk models improved their predictive capacity, marked by an overall elevation in Harrell C-indexes. IgG fucosylation was useful in further stratifying the intermediate-risk patients classified by a previously established model. Conclusions Plasma IgG fucosylation informs PAH prognosis independent of established factors, offering additional value for predicting PAH outcomes. (c) 2024 by the American College of Cardiology Foundation.
引用
收藏
页码:1092 / 1103
页数:12
相关论文
共 50 条
  • [1] PLASMA N-GLYCOME AS INCIDENCE HYPERTENSION PREDICTOR
    Cvetko, Ana
    Kifer, Domagoj
    Deris, Helena
    Cindric, Ana
    Spector, Tim D.
    Padmanabhan, Sandosh
    Lauc, Gordan
    Menni, Cristina
    JOURNAL OF HYPERTENSION, 2021, 39 : E110 - E110
  • [2] The N-Glycome of Human Plasma
    Stumpo, Katherine A.
    Reinhold, Vernon N.
    JOURNAL OF PROTEOME RESEARCH, 2010, 9 (09) : 4823 - 4830
  • [3] Serum immunoglobulin G N-glycome: a potential biomarker in endometrial cancer
    Lin, Sihan
    Wang, You
    Wang, Xinran
    Yan, Bin
    Lou, Weihua
    Di, Wen
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (12)
  • [4] Advancing Prognostic Biomarkers in Pulmonary Arterial Hypertension: The Role of Plasma Immunoglobulin G Fucosylation
    Wu, Qianwen
    Ye, Huangshu
    Zhou, Zhangdi
    Li, Dongyu
    Zhang, Miaojia
    Sun, Xiaoxuan
    Wang, Qiang
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2025, 28 (01)
  • [5] Heritability of Human Plasma N-Glycome
    Zaytseva, Olga O.
    Freidin, Maxim B.
    Keser, Toma
    Stambuk, Jerko
    Ugrina, Ivo
    Simurina, Mirna
    Vilaj, Marija
    Stambuk, Tamara
    Trbojevic-Akmacic, Irena
    Pucic-Bakovic, Maja
    Lauc, Gordan
    Williams, Frances M. K.
    Novokmet, Mislav
    JOURNAL OF PROTEOME RESEARCH, 2020, 19 (01) : 85 - 91
  • [6] Human Plasma IgG N-Glycome Profiles Reveal a Proinflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension
    Zhang, Ze-Jian
    Wang, Hui-Fang
    Lian, Tian-Yu
    Zhou, Yu-Ping
    Xu, Xi-Qi
    Guo, Fan
    Wei, Yun-Peng
    Li, Jing-Yi
    Sun, Kai
    Liu, Chao
    Pan, Lu-Rong
    Ren, Ming
    Nie, Lei
    Dai, Hai-Long
    Jing, Zhi-Cheng
    HYPERTENSION, 2023, 80 (09) : 1929 - 1939
  • [7] Association of Medication with the Human Plasma N-Glycome
    Saldova, Radka
    Huffman, Jennifer E.
    Adamczyk, Barbara
    Muzinic, Ana
    Kattla, Jayesh J.
    Pucic, Maja
    Novokmet, Mislay
    Abrahams, Jodie L.
    Hayward, Caroline
    Rudan, Igor
    Wild, Sarah H.
    Wright, Alan F.
    Polasek, Ozren
    Lauc, Gordan
    Campbell, Harry
    Wilson, James F.
    Rudd, Pauline M.
    JOURNAL OF PROTEOME RESEARCH, 2012, 11 (03) : 1821 - 1831
  • [8] Plasma N-Glycome Signature of Down Syndrome
    Borelli, Vincenzo
    Vanhooren, Valerie
    Lonardi, Emanuela
    Reiding, Karli R.
    Capri, Miriam
    Libert, Claude
    Garagnani, Paolo
    Salvioli, Stefano
    Franceschi, Claudio
    Wuhrer, Manfred
    JOURNAL OF PROTEOME RESEARCH, 2015, 14 (10) : 4232 - 4245
  • [9] Immunoglobulin G N-Glycome as a biomarker of mortality risk in Escherichia coli induced sepsis
    Wang, Huachen
    Li, Houqiang
    Guo, Zheng
    Hou, Hongda
    Hou, Haifeng
    Chen, Bing
    FRONTIERS IN IMMUNOLOGY, 2025, 16
  • [10] The analysis of the human plasma N-glycome in endometriosis patients
    Berkes, E.
    Muzinic, A.
    Rigo, J., Jr.
    Tinneberg, H. -R.
    Oehmke, F.
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2013, 171 (01) : 107 - 115