C-type natriuretic peptide (CNP): The cardiovascular system and beyond

被引：4
作者：
Dickinson, Yasmin A. [1 ]
Moyes, Amie J. [1 ]
Hobbs, Adrian J. [1 ]
机构：
[1] Queen Mary Univ London, William Harvey Res Inst, Fac Med & Dent, Barts & London, Charterhouse Sq, London EC1M 6BQ, England
来源：
PHARMACOLOGY & THERAPEUTICS | 2024年 / 262卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
C -type natriuretic peptide; Natriuretic peptide receptor; Cyclic GMP; G -protein coupled receptor; Heart; Vasculature; Kidney; Metabolism; Central nervous system; RECEPTOR NPR-B; MESANGIAL CELL-PROLIFERATION; CONGESTIVE-HEART-FAILURE; FIBROBLAST-GROWTH-FACTOR; OF-FUNCTION MUTATION; GUANYLYL CYCLASE; CLEARANCE RECEPTOR; BLOOD-PRESSURE; SINOATRIAL NODE; MOUSE MODEL;
D O I：
10.1016/j.pharmthera.2024.108708
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
C-type natriuretic peptide (CNP) represents the 'local' member of the natriuretic peptide family, functioning in an autocrine or paracrine capacity to modulate a hugely diverse portfolio of physiological processes. Whilst the bestcharacterised of these regulatory roles are in the cardiovascular system, akin to its predominantly endocrine siblings atrial (ANP) and brain (BNP) natriuretic peptides, CNP governs many additional, unrelated mechanisms including bone growth, gamete maturation, auditory processing, and neuronal integrity. Furthermore, there is currently great interest in mimicking the biological activity of CNP for therapeutic gain in many of these disparate organ systems. Herein, we provide an overview of the physiology, pathophysiology and pharmacology of CNP in both cardiovascular and non-cardiovascular settings. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://
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页数：18
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