Sex as a predictor of clinical phenotype and determinant of immune response in IgG4-related disease: a retrospective study of patients fulfilling the American College of Rheumatology-European League Against Rheumatism classification criteria

被引:5
作者
Jha, Isha [1 ]
Mcmahon, Grace A. [1 ]
Perugino, Cory A. [1 ,3 ,4 ]
Katz, Guy [1 ,3 ]
Wallace, Zachary S. [1 ,3 ,5 ]
Fernandes, Ana [1 ]
Jiang, Bohang [1 ,5 ]
Zhang, Yuqing [1 ]
Mcmahon, Aubree E. [1 ]
Guy, Thomas, V [3 ,4 ]
Liu, Hang [4 ]
Hernandez-Barco, Yasmin G. [2 ]
Pillai, Shiv [4 ]
Stone, John H. [1 ,3 ]
机构
[1] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA USA
[3] Harvard Med Sch, Boston, MA USA
[4] Ragon Inst Massachusetts Gen Hosp MIT & Harvard, Cambridge, MA USA
[5] Rheumatol & Allergy Clin Epidemiol Res Ctr, Boston, MA USA
基金
美国国家卫生研究院;
关键词
WEGENERS-GRANULOMATOSIS;
D O I
10.1016/S2665-9913(24)00089-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background IgG4-related disease is a multiorgan fibroinflammatory disease considered to have an autoimmune origin. Case series describing individual organ involvement have suggested differences in phenotypic expression between males and females. We aimed to characterise differences in IgG4-related disease manifestations between male and female patients in a large single-centre cohort. Methods In this retrospective, single-centre cohort study, patients were recruited from the Massachusetts General Hospital Rheumatology Clinic (Boston, MA, USA) and classified according to the American College of Rheumatology-European Alliance of Associations for Rheumatology (ACR-EULAR) classification criteria. Only patients satisfying the ACR-EULAR classification criteria were included in the study. Data on age at diagnosis, organ involvement at baseline, treatment status, and pre-treatment laboratory values were collected. Circulating plasmablasts and B-cell subsets were quantitated by flow cytometry. Active disease was defined by an IgG4-related disease Responder Index score of more than 0. Laboratory values were analysed for patients who were untreated at baseline and had active IgG4-related disease. The main outcomes were assessed in all participants with available data. Findings Of the 564 participants enrolled in the Massachusetts General Hospital Rheumatology Clinic IgG4-related disease Registry, 328 fulfilled ACR-EULAR classification criteria and were included between January, 2008, and May, 2023. There was a strong male predominance (male:female ratio 2<middle dot>2:1) with 226 (69%) males and 102 (31%) females, which contrasted markedly with our general rheumatology clinic population (0<middle dot>4:1; p<0<middle dot>001). The male predominance increased with each decade of life starting at age 40 years. On average, male patients were 5<middle dot>5 years older at diagnosis than female patients (63<middle dot>7 years vs 58<middle dot>2 years; p=0<middle dot>0031). We observed male patients to have higher ACR-EULAR classification criteria scores at baseline with a median score of 35<middle dot>0 (IQR 28<middle dot>0-46<middle dot>0), compared with 29<middle dot>5 (25<middle dot>0-39<middle dot>0) for females (p=0<middle dot>0010). The proportion of male patients with pancreatic and renal involvement was almost double the proportion observed in female patients (50% of the male patients had pancreatic involvement, compared with about 26% of the female patients; p<0<middle dot>0001). Male patients were more likely to have serological abnormalities at baseline. The distribution of IgG4 values differed significantly between male an female sexes, favouring higher values in males. We found that male patients with IgG4-related disease were more likely to have active B-cell responses in the blood as defined by plasmablast expansions. Interpretation IgG4-related disease is unusual among autoimmune diseases in that it is more likely to affect males than females and to present with a striking sex-dependent organ distribution and degree of B-cell response. These findings highlight important variation between IgG4-related disease and other conditions generally believed to have an autoimmune basis. Most autoimmune diseases, by contrast to IgG4-related disease, demonstrate pronounced predilections for affecting females more frequently than males. Hypotheses surrounding the cause and pathophysiology of this condition need to consider this unusual sex distribution among patients with IgG4-related disease.
引用
收藏
页码:e460 / e468
页数:9
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