Synthesis, Characterization, and Molecular Docking Studies of 3-Hydroxy2-(1-methyl-3-(trifluoromethyl)-1 H-pyrazole-4-carbonyl)cyclohex-2-en-1-ones

被引：1

作者：

Jin, Xin-Yu ^{[1
]}

Wang, Kui ^{[1
]}

Zhang, Pan-Xiu ^{[1
]}

Ye, Fei ^{[1
]}

机构：

[1] Northeast Agr Univ, Coll Arts & Sci, Dept Chem, Harbin 150030, Peoples R China

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 34卷 / 02期

关键词：

4-Hydroxyphenylpyruvate dioxygenase inhibitory; Molecular docking; Pyrazolylcyclohexanones; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; HYDROXYPHENYLPYRUVATE DIOXYGENASE; INHIBITION; HERBICIDES; DESIGN;

D O I：

10.59467/IJHC.2024.34.141

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new 3-hydroxy-2-(1-methyl-3-(trifluoromethyl)-1 H-pyrazole-4-carbonyl)cyclohex-2-en-1-ones ( 4a-c ) were synthesized using aromatic formic acid as starting material. The structures of the compounds were confirmed by spectral (infrared, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and HRMS) data. The molecular docking studies of the compounds were carried out to predict the possible 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitory activity. All the compounds exhibited activity in HPPD inhibitory.

引用

页码：141 / 145

页数：7

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