Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023

被引：9

作者：

Leeuwen, Leanne P. M. van ^{[1
,2
]}

Shamier, Marc C. ^{[1
]}

Verstrepen, Babs E. ^{[1
]}

Goetz, Hannelore ^{[3
]}

Schmitz, Katharina S. ^{[1
]}

Akhiyate, Najlae ^{[1
]}

Wijnans, Koen ^{[1
]}

Bogers, Susanne ^{[1
]}

van Royen, Martin E. ^{[4
]}

van Gorp, Eric C. M. ^{[1
,2
]}

Koopmans, Marion P. G. ^{[1
]}

de Vries, Rory D. ^{[1
]}

Geurtsvankessel, Corine H. ^{[1
]}

Zaeck, Luca M. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Virosci, Rotterdam, Netherlands

[2] Erasmus Univ, Travel Clin, Med Ctr Rotterdam, Rotterdam, Netherlands

[3] GGD Rotterdam Rijnmond, Dept Infect Dis Control, Municipal Publ Hlth Serv Rotterdam Rijnmond, Rotterdam, Netherlands

[4] Erasmus Univ, Med Ctr, Dept Pathol, Rotterdam, Netherlands

来源：

EUROSURVEILLANCE | 2024年 / 29卷 / 38期

关键词：

D O I：

10.2807/1560-7917.ES.2024.29.38.2400575

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara- Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated. Here, we demonstrate that orthopoxvirus-specific binding and MVA-neutralising antibodies waned to undetectable levels 1 year post vaccination in at-risk individuals who received two doses of MVA-BN administered subcutaneously with an interval of 4 weeks, without prior smallpox or mpox vaccination. Continuous surveillance is essential to understand the impact of declining antibody levels.

引用

页码：8 / 12

页数：5

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