Hematopoietic Stem Cells and Their Niche in Bone Marrow

被引：8

作者：

Kwon, Munju ^{[1
]}

Kim, Byoung Soo ^{[2
]}

Yoon, Sik ^{[3
]}

Oh, Sae-Ock ^{[3
]}

Lee, Dongjun ^{[1
,4
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Convergence Med, Yangsan 50612, South Korea

[2] Pusan Natl Univ, Sch Biomed Convergence Engn, Yangsan 50612, South Korea

[3] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan 50612, South Korea

[4] Pusan Natl Univ, Res Inst Convergence Biomed Sci & Technol, Transplantat Res Ctr, Yangsan Hosp, Yangsan 50612, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

hematopoietic stem cells; hematopoietic progenitor cells; bone marrow microenvironment; niche; ACUTE MYELOID-LEUKEMIA; BLOOD-VESSEL FORMATION; CLONAL HEMATOPOIESIS; ALLOGENEIC TRANSPLANTATION; IMMUNE RECOVERY; GROWTH-FACTOR; SELF-RENEWAL; SINGLE-CELL; OSTEOBLAST; MUTATIONS;

D O I：

10.3390/ijms25136837

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extensive research has explored the functional correlation between stem cells and progenitor cells, particularly in blood. Hematopoietic stem cells (HSCs) can self-renew and regenerate tissues within the bone marrow, while stromal cells regulate tissue function. Recent studies have validated the role of mammalian stem cells within specific environments, providing initial empirical proof of this functional phenomenon. The interaction between bone and blood has always been vital to the function of the human body. It was initially proposed that during evolution, mammalian stem cells formed a complex relationship with the surrounding microenvironment, known as the niche. Researchers are currently debating the significance of molecular-level data to identify individual stromal cell types due to incomplete stromal cell mapping. Obtaining these data can help determine the specific activities of HSCs in bone marrow. This review summarizes key topics from previous studies on HSCs and their environment, discussing current and developing concepts related to HSCs and their niche in the bone marrow.

引用

页数：18

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