Physician Modified fi ed Fenestrated Endografts for Endovascular Aortic Arch Repair in Zone 0

Objective: This multicentre study aimed to assess the early and midterm outcomes of physician modified fi ed fenestrated endografts (PMEGs) for endovascular aortic arch repair in zone 0. Methods: Between 2018 and 2022, a retrospective study was conducted in three centres of consecutive patients undergoing endovascular aortic arch repair in zone 0 with PMEGs. Endpoints included technical success, 30 day mortality rate, major adverse events, secondary interventions, stent stability, target vessel patency, and overall survival. Results: A total of 54 patients (mean age 63 years; 45 males) with aortic arch pathology were included, comprising aortic dissections (n n = 32; 59%) and aortic arch aneurysms (n n = 22; 41%). Technical success was 98%. One patient died from stroke within 30 days. Major adverse events included stroke (n n = 4; 7%), retrograde type A dissection (RTAD) (n n = 3; 6%), and acute kidney injury (n n = 2; 4%). During a median follow up of 12 months, there were two deaths (4%) of unknown cause at one month and 1.5 months, and no aortic related death. Type Ia, type Ic, and type IIIc endoleaks were observed in two (4%), three (6%), and two (4%) patients, respectively. No vessel stenosis was observed. Re-intervention was required in 10 patients (19%). Estimates of overall survival, freedom from secondary intervention, and freedom from target vessel instability at one year were 94.2% (standard error [SE] 3.3%), 81.8% (SE 6.0%), and 92.0% (SE 4.5%), respectively. Conclusion: This study has demonstrated the efficacy fi cacy of PMEGs for zone 0 endovascular aortic arch repair, with acceptable technical success and mortality rates. Stroke, RTAD, and re-intervention rates remain a concern for endovascular therapy. A larger population and long term outcomes are required to assess the safety and durability of this technique as a beneficial fi cial choice for endovascular aortic arch repair in specialised centres.