Thymic development of human natural killer T cells: recent advances and implications for immunotherapy

被引：0
作者：
Pellicci, Daniel G. [1 ,2 ,3 ]
Tavakolinia, Naeimeh [1 ,2 ]
Perriman, Louis [1 ,4 ,5 ]
Berzins, Stuart P. [2 ,5 ]
Menne, Christopher [1 ]
机构：
[1] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia
[3] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
[4] Fiona Elsey Canc Res Inst, Ballarat, Vic, Australia
[5] Federat Univ Australia, Ballarat, Vic, Australia
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
unconventional T cells; unconventional T cell development; cytokines; cytotoxic granules; immunotherapy; INVARIANT NKT CELLS; TRANSCRIPTION FACTOR PLZF; MONOCLONAL-ANTIBODY; ANTITUMOR-ACTIVITY; HUMAN INKT; LINEAGE; SUBSETS; CD4(+); CD1D; EXPRESSION;
D O I：
10.3389/fimmu.2024.1441634
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Invariant natural killer T (iNKT) cells are a subset of lipid-reactive, unconventional T cells that have anti-tumor properties that make them a promising target for cancer immunotherapy. Recent studies have deciphered the developmental pathway of human MAIT and V gamma 9V delta 2 gamma delta-T cells as well as murine iNKT cells, yet our understanding of human NKT cell development is limited. Here, we provide an update in our understanding of how NKT cells develop in the human body and how knowledge regarding their development could enhance human treatments by targeting these cells.
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页数：10
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