Applications of 4-alkynylated pyrazol-3-ones: Synthesis of pyrazol-4-yl furan- and/or thiophene-2-carboxylates

被引：0

作者：

Fujita, Takafumi ^{[1
]}

Okabe-Nakahara, Fumi ^{[1
]}

Maruoka, Hiroshi ^{[1
]}

Masumoto, Eiichi ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka, Japan

来源：

SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 16期

关键词：

Acylation; alkynylation; propargyl alcohol; pyrazole; ring transformation; DNA CLEAVAGE ACTIVITY; SPIRO PYRAZOL-3-ONES; PROPARGYLIC ALCOHOLS; ASYMMETRIC-SYNTHESIS; DERIVATIVES; ALKYNYLATION; COMPLEX; DESIGN;

D O I：

10.1080/00397911.2024.2385539

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical reactivity and applications of 4-alkynylated pyrazol-3-ones are described. A facile access to the synthesis of novel pyrazol-4-yl furan- and/or thiophene-2-carboxylates through the ring transformation and subsequent acylation of 4-alkynylated pyrazol-3-ones as the key intermediates, which were prepared from pyrazole-4,5-dione and terminal alkynes, in moderate to good yields is achieved. All the synthesized compounds were characterized by spectroscopic analysis. [GRAPHICS]

引用

页码：1321 / 1331

页数：11

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